Detailed information of TA system TA194822

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symER/SymE(toxin)
• Location: 3601748..3602160
• Replicon: chromosome
• Accession: NZ_CP070962
• Organism: Escherichia coli strain K-12 J53

Toxin (Protein)

• Gene name: symE
• Uniprot ID: U9YSY7
• Locus tag: JTR57_RS17615
• Protein ID: WP_000132601.1
• Coordinates: 3601819..3602160 (+)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	symR
Locus tag	-
Coordinates	3601748..3601824 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JTR57_RS17605 (3598611)	3598611..3600200	+	1590	WP_001063204.1	type I restriction-modification system methyltransferase	-
JTR57_RS17610 (3600197)	3600197..3601591	+	1395	WP_001272447.1	type I restriction-modification system specificity subunit	-
- (3601748)	3601748..3601824	-	77	NuclAT_14	-	Antitoxin
- (3601748)	3601748..3601824	-	77	NuclAT_14	-	Antitoxin
- (3601748)	3601748..3601824	-	77	NuclAT_14	-	Antitoxin
- (3601748)	3601748..3601824	-	77	NuclAT_14	-	Antitoxin
- (3601748)	3601748..3601824	-	77	NuclAT_15	-	Antitoxin
- (3601748)	3601748..3601824	-	77	NuclAT_15	-	Antitoxin
- (3601748)	3601748..3601824	-	77	NuclAT_15	-	Antitoxin
- (3601748)	3601748..3601824	-	77	NuclAT_15	-	Antitoxin
JTR57_RS17615 (3601819)	3601819..3602160	+	342	WP_000132601.1	endoribonuclease SymE	Toxin
JTR57_RS17620 (3602322)	3602322..3603701	+	1380	WP_000443951.1	5-methylcytosine-specific restriction endonuclease subunit McrB	-
JTR57_RS17625 (3603701)	3603701..3604747	+	1047	WP_000437621.1	5-methylcytosine-specific restriction endonuclease system specificity protein McrC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12203.02 Da
• Isoelectric Point: 8.5012

>T194822 WP_000132601.1 NZ_CP070962:3601819-3602160 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T194822 NZ_CP094096:c1146295-1146014 [Helicobacter pylori]
ATGCTTAAAGTCAGAACTAAGAAAGATTTTCTTAAAGACTTTAATAAACATATCTTATCTGGGCGTATTACAGAAAGCGA
TGTTACAAGCGTTGTTGATTGTCTCAAAGAGCAAAAACCGCTCCAACAAAAATATTGCGACCATGCCTTAAGTGGCAATC
TTAAAGGGTTGAGAGAATGCCATGTCAAGCCAAACTTGTTATTGATTTATGAAATCAAAAAACAAGAAAACGAACTTGTT
TTATTGCGTCTAGACACTCACAGCGAGCTATTTAAAAAGTGA

Antitoxin

Nucleotide

• Length: 77 bp

>AT194822 NZ_CP070962:c3601824-3601748 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: U9YSY7

Antitoxin