194806

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1473850..1474352 Replicon chromosome
Accession NZ_CP070962
Organism Escherichia coli strain K-12 J53

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag JTR57_RS07045 Protein ID WP_000767829.1
Coordinates 1474098..1474352 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag JTR57_RS07040 Protein ID WP_001259255.1
Coordinates 1473850..1474101 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JTR57_RS07015 (1469028) 1469028..1470095 - 1068 WP_000080105.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
JTR57_RS07020 (1470095) 1470095..1471165 - 1071 WP_000108941.1 histidinol-phosphate transaminase -
JTR57_RS07025 (1471162) 1471162..1472466 - 1305 WP_000009594.1 histidinol dehydrogenase -
JTR57_RS07030 (1472472) 1472472..1473371 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
JTR57_RS07035 (1473517) 1473517..1473567 - 51 WP_001364200.1 his operon leader peptide -
JTR57_RS07040 (1473850) 1473850..1474101 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
JTR57_RS07045 (1474098) 1474098..1474352 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
JTR57_RS07050 (1474435) 1474435..1475259 + 825 WP_000754737.1 SDR family oxidoreductase -
JTR57_RS07055 (1475305) 1475305..1476234 + 930 WP_000803351.1 LysR substrate-binding domain-containing protein -
JTR57_RS07060 (1476449) 1476449..1476511 + 63 WP_010723108.1 membrane protein YoeI -
JTR57_RS07065 (1476501) 1476501..1477859 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
JTR57_RS07070 (1478038) 1478038..1479096 + 1059 WP_000492339.1 thiosulfate utilization transporter TsuA/YeeE -
JTR57_RS07075 (1479110) 1479110..1479337 + 228 WP_000234896.1 sulfurtransferase TusA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T194806 WP_000767829.1 NZ_CP070962:1474098-1474352 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T194806 NZ_CP094083:20818-21597 [Helicobacter pylori]
ATGGAAACTAAAGAAGAGGATAAAGATAAAAAGCTAGAAGAAATTATTGTATTGCTGTGCGAAGAGGGGGATTTGTCTAG
TCAAAAAGATCAAATCATCAAAGATCTCAAAGAAATCTATGAAGGAGAATACAAGCATAAATACTCAAAAATCACAACTA
TTATTTTAAATTCCACAAGGGATAAAGAGCAAGCCTTTATGATGCTCACACAAAATATAAAGACACTCAAAGAGATTCAA
GATAACAAAGAAGTTGAAAGCATTAAACCAAAATTAGAAAAGCTTTATGATCACATGAATTTAGAGTGTATTAGACTGCA
AGATTTTGATGAGAAAATGAGTAGAGTTAAAGATATTTCTATAAAGTTAGATAATCTAAATAAAAACTATAAAAAATTAA
GCGAAGAATTGAATAAGCAACAAACACAATACATAACAATTTTAGGTATTTTTGCCTCTATTGTTTTAACATTTGTTGGG
GGATTGGCGTTTTCCACTTCTGTTTTATCAAATATTGACAAAGCGAACGCCTATCGTTTGGTTTTTGTTATGGCTTTTAT
AGCTTTATTTTTTGGGAATATTTTGTATCTGCTTTTTTCTTTTTTATCAAAAATATCCTTATCATCAAAAATATCCTTAT
CAGAAGAGGAAAAAGATAAACAAGAAAATTTTTTCAAAAAACCTATTTTTTGGTTTAATCTAATGGTTACAATTCTATTT
GTGATTGGTTTTTTTGGAGAATTGTATATAATACAAAGGTTAGTTTCTAAATATCTTTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT194806 WP_001259255.1 NZ_CP070962:1473850-1474101 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT194806 NZ_CP094083:20391-20828 [Helicobacter pylori]
ATGGTCAATACTTTGGAATTAGCAAAATATATTCTTAAGCGTTCCAACAAAGAATTGAGCAACTTAGAATTGCAAAAAAC
TTTGTATTTCACAGAGCTTGACTATATTAAAAAGTTTGGCAAACACCTAGTTTCTGATGATTTTGAAGCTTGGAAATACG
GGCCTATTGCCAGGGAAGTGTATTATGAATATCGCAATTATGGTGCCAATCCTATTGACAAACCCAAAAAAGAAACGCTC
TCACAAAATCTTAGAGAAGATGAACTTGAAACCATTAATCGCTCCATAAAAAAATGCAACGAAAAATCCTATTGGGATTT
AGTGAAAGAGAGCCATAAAGAAGATGGCGCTTGGCATAAAAGCTTCAAAGAAGATAGAAAAGAAATCATTAGCAAAGATT
TGATCAAACAAGAAGCAAAACAAGCAAATGGAAACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References