Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 406518..407211 Replicon chromosome
Accession NZ_CP070962
Organism Escherichia coli strain K-12 J53

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag JTR57_RS02060 Protein ID WP_000415584.1
Coordinates 406518..406814 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag JTR57_RS02065 Protein ID WP_000650107.1
Coordinates 406816..407211 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JTR57_RS02025 (401606) 401606..401920 - 315 WP_000958598.1 putative quinol monooxygenase -
JTR57_RS02030 (401951) 401951..402532 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
JTR57_RS02035 (402851) 402851..403183 + 333 WP_000917684.1 DUF2645 family protein -
JTR57_RS02040 (403229) 403229..404578 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
JTR57_RS02045 (404575) 404575..405234 - 660 WP_001221495.1 quorum sensing response regulator transcription factor QseB -
JTR57_RS02050 (405386) 405386..405778 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
JTR57_RS02055 (405831) 405831..406313 + 483 WP_000183505.1 GyrI-like domain-containing protein -
JTR57_RS02060 (406518) 406518..406814 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
JTR57_RS02065 (406816) 406816..407211 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
JTR57_RS02070 (407344) 407344..408951 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
JTR57_RS02075 (409089) 409089..411347 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T194801 WP_000415584.1 NZ_CP070962:406518-406814 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T194801 NZ_CP094080:c150631-150350 [Helicobacter pylori]
ATGCTTAAAGTCAGAACTAAGAAAGATTTTCTTAAAGACTTTAATAAGCATATCTTATCTGGGCGTATTACAGAAAGCGA
TGTTACGAGCGTTGTTGATTGTCTCAAAGAGCAAAAACCACTCCAACAAAAATATTGCGACCATGCCTTGAGTGGCAATC
TTAAAGGGTTGAGAGAGTGTCATGTCAAGCCAAACTTGTTATTGATTTATGAAATCAAAAAACAAGAAAACGAACTTGTT
TTATTGCGTCTAGACACTCATAGCGAGCTATTTAAAAAGTGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT194801 WP_000650107.1 NZ_CP070962:406816-407211 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT194801 NZ_CP094080:c150938-150624 [Helicobacter pylori]
ATGTCAAATATTATTACAGATTACTCGCAATACAATGAAAAGCAACTGCACAATTTCTTAAACGCCATTGAAAAACAATG
GCTTAAGGCAGAAGGGGATAAAAATAAGGCGATAAAAAAAATCCAAGAGTGTGAATTGCAAGAACAAATGATCAGACAAG
TTTTAGCCCAAAAACATTCTCAAGAAAAAGAACCCACACAAAGTTTGTTAAATACGATCGCCTCAAAAGATGACCCAGAA
TGCGATGTTTCGTTTGGAGACTTCAATGATTTTTTACAAATAGCAAAACAAGAAAGAGAAAGGCATAATGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References