Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2374081..2374658 Replicon chromosome
Accession NZ_CP070959
Organism Thiomicrospira microaerophila strain BDL05

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag JX580_RS11580 Protein ID WP_248850696.1
Coordinates 2374081..2374359 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JX580_RS11585 Protein ID WP_248850697.1
Coordinates 2374359..2374658 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JX580_RS11555 (JX580_11570) 2369287..2369526 - 240 WP_248850691.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
JX580_RS11560 (JX580_11575) 2369654..2371378 - 1725 WP_248850692.1 DUF1538 domain-containing protein -
JX580_RS11565 (JX580_11580) 2371392..2372894 - 1503 WP_248850693.1 DUF1538 domain-containing protein -
JX580_RS11570 (JX580_11585) 2372901..2373302 - 402 WP_248850694.1 CBS domain-containing protein -
JX580_RS11575 (JX580_11590) 2373302..2373652 - 351 WP_248850695.1 hypothetical protein -
JX580_RS11580 (JX580_11595) 2374081..2374359 + 279 WP_248850696.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JX580_RS11585 (JX580_11600) 2374359..2374658 + 300 WP_248850697.1 HigA family addiction module antitoxin Antitoxin
JX580_RS11600 (JX580_11615) 2375151..2375948 + 798 WP_248850698.1 Cof-type HAD-IIB family hydrolase -
JX580_RS11605 (JX580_11620) 2375963..2377321 - 1359 WP_248850699.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
JX580_RS11610 (JX580_11625) 2377323..2378048 - 726 WP_248850700.1 VacJ family lipoprotein -
JX580_RS11615 (JX580_11630) 2378076..2378993 - 918 WP_248850701.1 hydrogen peroxide-inducible genes activator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-66)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10491.98 Da        Isoelectric Point: 9.5643

>T194798 WP_248850696.1 NZ_CP070959:2374081-2374359 [Thiomicrospira microaerophila]
MIKSFKHKGLRQFFEAGSVAGIQAPHTKKLRMQLAAIDTAQQIEDINLPGFRLHPLKGERAGIWSISVSGNWRITFEFTD
GNAYILNYEDYH

Download         Length: 279 bp

>T194798 NZ_CP094076:c513050-512769 [Helicobacter pylori]
ATGCTTAAAGTCAGAACTAAGAAAGATTTTCTTAAAGACTTTAATAAGCATATCTTATCCGGGCGTATTAAAGAAAGCGA
TGTTACAAGCATTGTTGATTGCCTCAAAGAGCAAAAACCACTCCAACAAAAATATTGCGACCATGCCTTGAGCGGTAATC
TTAAAGGGCTGAGAGAGTGTCATGTCAAGCCAAACTTGTTATTGATTTATGAAATCAAAAAACAAGAAAACGAACTTGTT
TTATTGCGTCTAGACACTCATAGCGAGCTATTTAAAAAGTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11145.75 Da        Isoelectric Point: 6.9879

>AT194798 WP_248850697.1 NZ_CP070959:2374359-2374658 [Thiomicrospira microaerophila]
MTMHNPPHPGEFIESVYLEDTGLSGRQLAEHLDVAPSTIQRILKGKSGVTPDMALRLSRVLGRTPESWLAMQANYDLWHA
KQNAYFLSLKPISLHSEFT

Download         Length: 300 bp

>AT194798 NZ_CP094076:c513357-513043 [Helicobacter pylori]
ATGTCAAATATTATTACAGATTACTCACAATATAATGAAAAGCAACTGCACAATTTCTTAAACGCCATTGAAAGACGATT
GCTTAAAGCAGAAGGGGATAAAAATAAGGCGATAAAAAAAATCCAAGAGTGTGAATTGCAAGAACAAATGATCAGACAAG
TTTTAGCCCAAAAACATTCTCAAGAAAAAGAACCCACACAAAGTTTGTTAAATACGATCGCTTCAAAAGATGACCCAGAA
TACGATGTTTCGTTTGGAGATTTCAATGATTTTTTACAAATAGCAAAACAAGAAAGAGAAAGGCATAATGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References