Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 3951057..3951856 Replicon chromosome
Accession NZ_CP070954
Organism Escherichia fergusonii strain EF44

Toxin (Protein)


Gene name yhaV Uniprot ID F0JQM9
Locus tag JYG65_RS18825 Protein ID WP_000347270.1
Coordinates 3951392..3951856 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID B7LMV4
Locus tag JYG65_RS18820 Protein ID WP_015953962.1
Coordinates 3951057..3951392 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JYG65_RS18805 (3947181) 3947181..3948071 - 891 WP_000178100.1 2-hydroxy-3-oxopropionate reductase -
JYG65_RS18810 (3948096) 3948096..3948866 - 771 WP_001058567.1 2-dehydro-3-deoxyglucarate aldolase -
JYG65_RS18815 (3949337) 3949337..3950908 + 1572 WP_223666554.1 galactarate dehydratase -
JYG65_RS18820 (3951057) 3951057..3951392 + 336 WP_015953962.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
JYG65_RS18825 (3951392) 3951392..3951856 + 465 WP_000347270.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
JYG65_RS18830 (3951911) 3951911..3952720 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
JYG65_RS18835 (3952968) 3952968..3954248 + 1281 WP_223666555.1 tagatose-bisphosphate aldolase subunit KbaZ -
JYG65_RS18840 (3954271) 3954271..3954744 + 474 WP_032303829.1 PTS N-acetylgalactosamine transporter subunit IIB -
JYG65_RS18845 (3954755) 3954755..3955534 + 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
JYG65_RS18850 (3955524) 3955524..3956402 + 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
JYG65_RS18855 (3956420) 3956420..3956854 + 435 WP_032303830.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17806.22 Da        Isoelectric Point: 9.6924

>T194776 WP_000347270.1 NZ_CP070954:3951392-3951856 [Escherichia fergusonii]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEEAH

Download         Length: 465 bp

>T194776 NZ_CP094059:568812-569084 [Helicobacter pylori]
ATGCTGATGATTGAAACCAGTAAAAAATTTGATAAGGATCTTAAAATTCTTGTTAAAAACGGGTTTGATTTAAAGCTTTT
ATATAAAGTGGTTGAAAATTTAGCCAAAGAGCAACCCCTAGATTCCAAATACAAAGACCACCCGCTCAAGGGCGTTTTAA
AAGATTTTAGGGAATGCCACCTGAAACCGGATTTATTGCTTGTCTATCAAATTAAAAAACAAGAAAACACCCTCTTTTTA
GTAAGACTAGGCAGTCATAGCGAGCTGTTTTAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12281.89 Da        Isoelectric Point: 4.4128

>AT194776 WP_015953962.1 NZ_CP070954:3951057-3951392 [Escherichia fergusonii]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDPTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT194776 NZ_CP094059:568514-568825 [Helicobacter pylori]
ATGCCTAATTCTCCCACCAAAAAAGACTACACGCAATACAGTGAAAAACAGCTTTTTAACTTTTTAAATTCTATCAAGAC
CAAACAAAAAAGAGCGTTAGAAAAATTGAAAGAAATCCAAGTTCAAAAACAAAGAATCAAAAAAGCGCTCCAATTTAAAG
CGCTCCATTTAACCGAAAACGGATACACCATAGAAGAAGAGCGAGAAATCTTAGCAAGGGCTAAAGACACCAAGAACCAC
CTTTGTTTTAAAAATATAGAGGATTTTAAAAAGCATTGTGAAAACTTAAGATTTAAAAATGCTGATGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0V9NQ90

Antitoxin

Source ID Structure
AlphaFold DB B7LMV4

References