Detailed information of TA system TA194774

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3865022..3865280
• Replicon: chromosome
• Accession: NZ_CP070954
• Organism: Escherichia fergusonii strain EF44

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: JYG65_RS18360
• Protein ID: WP_000809168.1
• Coordinates: 3865128..3865280 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	3865022..3865079 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JYG65_RS18335	3860824..3861765	-	942	WP_104918205.1	bifunctional riboflavin kinase/FAD synthetase	-
JYG65_RS18340	3861773..3861991	-	219	WP_001353471.1	DUF2575 family protein	-
JYG65_RS18345	3862094..3862357	+	264	WP_001274021.1	30S ribosomal protein S20	-
JYG65_RS18350	3862453..3863352	-	900	WP_000019050.1	transcriptional activator NhaR	-
JYG65_RS18355	3863420..3864586	-	1167	WP_000681374.1	Na+/H+ antiporter NhaA	-
-	3865022..3865079	-	58	-	-	Antitoxin
JYG65_RS18360	3865128..3865280	+	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
JYG65_RS18365	3865358..3866470	+	1113	WP_001300563.1	IS4-like element IS421 family transposase	-
JYG65_RS18370	3866734..3867864	-	1131	WP_001470960.1	molecular chaperone DnaJ	-
JYG65_RS18375	3867953..3869869	-	1917	WP_000516135.1	molecular chaperone DnaK	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T194774 WP_000809168.1 NZ_CP070954:3865128-3865280 [Escherichia fergusonii]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T194774 NZ_CP094056:579069-579335 [Helicobacter pylori]
GTGTTGAAACTCAACCTTAAAAAATCTTTTCAAAAAGATTTTGATAAATTACTTTTGAATGGGTTTGATGATAGCGTTTT
GAATAAGGTCATTCTGTCTTTGAGAAAAAAAGAACCGCTAGACCCACAATTTCAAGATCATGCTTTAAAGGGAAAGTGGA
AACCTTTTAGGGAATGCCACATCAAAGCTGATACTTTGCTTGTGTATTTAGTGAAAGGTGATGAGCTTATTTTAGTAAGA
CTAGGCAGTCATAGCGAGCTGTTTTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT194774 NZ_CP070954:c3865079-3865022 [Escherichia fergusonii]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin