Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 3561864..3562110 Replicon chromosome
Accession NZ_CP070954
Organism Escherichia fergusonii strain EF44

Toxin (Protein)


Gene name hokX Uniprot ID S1PD89
Locus tag JYG65_RS16990 Protein ID WP_000956458.1
Coordinates 3561864..3562016 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokX
Locus tag -
Coordinates 3562058..3562110 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JYG65_RS16975 3557043..3558080 + 1038 WP_000490451.1 aminopeptidase -
JYG65_RS16980 3558678..3560322 - 1645 Protein_3324 CRISPR-associated endonuclease Cas3'' -
JYG65_RS16985 3560559..3561671 + 1113 WP_001300563.1 IS4-like element IS421 family transposase -
JYG65_RS16990 3561864..3562016 - 153 WP_000956458.1 Hok/Gef family protein Toxin
- 3562058..3562110 + 53 - - Antitoxin
JYG65_RS16995 3562280..3563014 - 735 WP_223667723.1 phosphoadenosine phosphosulfate reductase -
JYG65_RS17000 3563088..3564800 - 1713 WP_223667725.1 assimilatory sulfite reductase (NADPH) hemoprotein subunit -
JYG65_RS17005 3564800..3566605 - 1806 WP_223667727.1 NADPH-dependent assimilatory sulfite reductase flavoprotein subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(5-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5558.77 Da        Isoelectric Point: 7.6757

>T194772 WP_000956458.1 NZ_CP070954:c3562016-3561864 [Escherichia fergusonii]
MLTKYALVAIIVLCCTVLGFTLMVGDSLCELSIRERGMEFKAVLAYESKK

Download         Length: 153 bp

>T194772 NZ_CP094052:594159-594425 [Helicobacter pylori]
ATGCTGAAAATTAAGCACCATATCCTTTACAAAAAAGATTTTAAAAAACTTATCAAAAACGGGTTTGATGATAGCGTTTT
GAATAAGGTCATTCTGTCTTTGAGAAAAAAAGAACCGCTAGATCCCCAATTTAAAGATCATGCTTTAAAGGGAAAGTGGA
AACCTTTTAGGGAATGCCACATCAAAGCTGATATTTTGCTTGTCTATTTAGTGAAAGATGATGAGCTTATTTTAGTAAGA
CTAGGCAGTCATAGCGAGCTGTTTTAA

Antitoxin


Download         Length: 53 bp

>AT194772 NZ_CP070954:3562058-3562110 [Escherichia fergusonii]
TTAGGTTCGAACGCTGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TJ83

Antitoxin

Download structure file

References