Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
| Location | 1769824..1770326 | Replicon | chromosome |
| Accession | NZ_CP070954 | ||
| Organism | Escherichia fergusonii strain EF44 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | U9YDH0 |
| Locus tag | JYG65_RS08295 | Protein ID | WP_000767829.1 |
| Coordinates | 1770072..1770326 (+) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | S1Q063 |
| Locus tag | JYG65_RS08290 | Protein ID | WP_001259255.1 |
| Coordinates | 1769824..1770075 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JYG65_RS08265 (1765001) | 1765001..1766068 | - | 1068 | WP_000080087.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
| JYG65_RS08270 (1766068) | 1766068..1767138 | - | 1071 | WP_223666911.1 | histidinol-phosphate transaminase | - |
| JYG65_RS08275 (1767135) | 1767135..1768439 | - | 1305 | WP_046083400.1 | histidinol dehydrogenase | - |
| JYG65_RS08280 (1768445) | 1768445..1769344 | - | 900 | WP_000131782.1 | ATP phosphoribosyltransferase | - |
| JYG65_RS08285 (1769490) | 1769490..1769540 | - | 51 | WP_001364200.1 | his operon leader peptide | - |
| JYG65_RS08290 (1769824) | 1769824..1770075 | + | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
| JYG65_RS08295 (1770072) | 1770072..1770326 | + | 255 | WP_000767829.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
| JYG65_RS08300 (1770409) | 1770409..1771233 | + | 825 | WP_000754745.1 | SDR family oxidoreductase | - |
| JYG65_RS08305 (1771279) | 1771279..1772208 | + | 930 | WP_000803361.1 | LysR substrate-binding domain-containing protein | - |
| JYG65_RS08310 (1772422) | 1772422..1772484 | + | 63 | WP_010723108.1 | membrane protein YoeI | - |
| JYG65_RS08315 (1772474) | 1772474..1773832 | + | 1359 | WP_000019201.1 | putrescine/proton symporter PlaP | - |
| JYG65_RS08320 (1774011) | 1774011..1775069 | + | 1059 | WP_223666912.1 | thiosulfate utilization transporter TsuA/YeeE | - |
| JYG65_RS08325 (1775083) | 1775083..1775310 | + | 228 | WP_000985273.1 | thiosulfate utilization sulfurtransferase TsuB/YeeD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10183.58 Da Isoelectric Point: 8.0353
>T194761 WP_000767829.1 NZ_CP070954:1770072-1770326 [Escherichia fergusonii]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T194761 NZ_CP093967:c143962-143681 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCCCTGAAAGCCGTCCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCTTTTCGGGTAAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTAA
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCCCTGAAAGCCGTCCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCTTTTCGGGTAAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT194761 WP_001259255.1 NZ_CP070954:1769824-1770075 [Escherichia fergusonii]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT194761 NZ_CP093967:c144186-143959 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|