Detailed information of TA system TA194753

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 300875..301132
• Replicon: chromosome
• Accession: NZ_CP070954
• Organism: Escherichia fergusonii strain EF44

Toxin (Protein)

• Gene name: hokA
• Uniprot ID: -
• Locus tag: JYG65_RS01360
• Protein ID: WP_001135723.1
• Coordinates: 300980..301132 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokA
Locus tag	-
Coordinates	300875..300923 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JYG65_RS01340	296867..297166	+	300	WP_223666502.1	YsaB family lipoprotein	-
JYG65_RS01345	297262..298173	+	912	WP_001168544.1	glycine--tRNA ligase subunit alpha	-
JYG65_RS01350	298183..300252	+	2070	WP_001291786.1	glycine--tRNA ligase subunit beta	-
JYG65_RS01355	300321..300680	+	360	WP_148047754.1	hypothetical protein	-
-	300875..300923	-	49	-	-	Antitoxin
JYG65_RS01360	300980..301132	+	153	WP_001135723.1	type I toxin-antitoxin system toxin HokA	Toxin
JYG65_RS01365	301109..301180	-	72	WP_216665726.1	hypothetical protein	-
JYG65_RS01370	301290..301661	+	372	WP_001037803.1	membrane protein insertion efficiency factor YidD	-
JYG65_RS01375	301715..301927	-	213	WP_000014594.1	RNA chaperone/antiterminator CspA	-
JYG65_RS01380	302209..302499	-	291	WP_000455800.1	HTH-type transcriptional regulator	-
JYG65_RS01385	302749..304119	-	1371	WP_000184983.1	MFS transporter	-
JYG65_RS01390	304557..305267	+	711	WP_000190514.1	DUF3053 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5899.14 Da
• Isoelectric Point: 6.9160

>T194753 WP_001135723.1 NZ_CP070954:300980-301132 [Escherichia fergusonii]
MPQKYGLLSLIVICFTLLFFTWMIRDSLCELHIKQESYELAAFLACKLKE

Nucleotide

• Length: 153 bp

>T194753 NZ_CP093965:3514046-3514624 [Pseudomonas aeruginosa]
ATGTCCCTCGAACTGCTGAGCAACCGCCTCGAATTCCTCCGCGAAGCCGAACGCCTGAAAGACGTCCTGCGCTCCGCGCA
CACCTCCTCCGGCCGCCCGGAAAGCACCGCCGAACATAGCTGGCGGCTGTGCCTGATGGCACTGGCCTTCGAGGACCAAC
TGGCCGGCCTGGACCTCGGCAAGGTCCTGCGCATGTGCGTGGTCCACGACCTCGGCGAAGCGATCCACGGCGACATCCCC
GCCGTCGAGCAGGCTGCGCACCCGGACAAAGGCGAACAGGAACGCGCCGACCTGTTGCAGCTGACCCGTCACCTCGACGC
GCCGCTGCGCGACCGCCTGCTCGCCCTGTGGGACGAATACGAGCGCGGCGAGTCCGCCGAAGCCCTGGCAGTGAAGGCCC
TGGACAAGCTGGAAACCCTGCTCCAGCACACCCAGGGCGACAATCCGGCGGACTTCGACTATGCCTTCAACCTCGACTAC
GGCCGTCGCTATACCGACCGCGCACCGCTGTTCAAGACCCTGCGCGAGCTACTCGACGCCAGGACCCGACAGCGCCTCGC
AGCTCGGCGCGACGCCTAG

Antitoxin

Nucleotide

• Length: 49 bp

>AT194753 NZ_CP070954:c300923-300875 [Escherichia fergusonii]
GCATAGAGGGGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Structures

Antitoxin