Detailed information of TA system TA194747

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 4240928..4241186
• Replicon: chromosome
• Accession: NZ_CP070951
• Organism: Escherichia fergusonii strain EF31

Toxin (Protein)

• Gene name: hokA
• Uniprot ID: -
• Locus tag: JW961_RS20375
• Protein ID: WP_001135723.1
• Coordinates: 4240928..4241080 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokA
Locus tag	-
Coordinates	4241131..4241186 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JW961_RS20345	4236792..4237502	-	711	WP_000190514.1	DUF3053 domain-containing protein	-
JW961_RS20350	4237940..4239310	+	1371	WP_000184983.1	MFS transporter	-
JW961_RS20355	4239560..4239850	+	291	WP_000455800.1	HTH-type transcriptional regulator	-
JW961_RS20360	4240132..4240344	+	213	WP_000014594.1	RNA chaperone/antiterminator CspA	-
JW961_RS20365	4240398..4240769	-	372	WP_001037804.1	membrane protein insertion efficiency factor YidD	-
JW961_RS20370	4240880..4240951	+	72	WP_216665726.1	hypothetical protein	-
JW961_RS20375	4240928..4241080	-	153	WP_001135723.1	type I toxin-antitoxin system toxin HokA	Toxin
-	4241131..4241186	+	56	-	-	Antitoxin
JW961_RS20380	4241403..4243472	-	2070	WP_001291786.1	glycine--tRNA ligase subunit beta	-
JW961_RS20385	4243482..4244393	-	912	WP_001168544.1	glycine--tRNA ligase subunit alpha	-
JW961_RS20390	4244489..4244788	-	300	WP_024256552.1	YsaB family lipoprotein	-
JW961_RS20395	4244960..4245955	+	996	WP_015953832.1	acyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5899.14 Da
• Isoelectric Point: 6.9160

>T194747 WP_001135723.1 NZ_CP070951:c4241080-4240928 [Escherichia fergusonii]
MPQKYGLLSLIVICFTLLFFTWMIRDSLCELHIKQESYELAAFLACKLKE

Nucleotide

• Length: 153 bp

>T194747 NZ_CP093957:851271-851612 [Enterococcus faecalis]
ATGAACGTTGAAAAGAAGTACATTCCCAAAAAAGGAGATATTGTATGGATTGATTTTGATCCTGCTGCAGGTAAAGAAAT
TCAGAAGAGACGGCCTGGTTTAGTCGTGTCAAGATATGAATTTAATCGGAAAACCATGTTTGCTGTGATTTGCCCGATTA
CTTCCACCATTAAAAATATTCCCACTCGATATACGTTGCCCGATGACATAGAAACCCAAGGACAAGTAGTGATCTCACAA
CTGAAATCTTTGGACTTCACTGAAAGAAAATTAAGTCAAATTGAGCATTTGCCATTAAAAGATATGGCGAAAATTGACCA
AATAATTGAATATATTTTCTAG

Antitoxin

Nucleotide

• Length: 56 bp

>AT194747 NZ_CP070951:4241131-4241186 [Escherichia fergusonii]
GTTGAAGCATAGAGGCAGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Structures

Antitoxin