Detailed information of TA system TA194727

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 639074..639332
• Replicon: chromosome
• Accession: NZ_CP070951
• Organism: Escherichia fergusonii strain EF31

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: -
• Locus tag: JW961_RS03100
• Protein ID: WP_046082123.1
• Coordinates: 639074..639226 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	639275..639332 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JW961_RS03080	634140..634727	+	588	WP_002431696.1	molybdopterin adenylyltransferase	-
JW961_RS03085	634761..635327	-	567	WP_000528529.1	acetate uptake transporter	-
JW961_RS03090	635834..637750	+	1917	WP_000516135.1	molecular chaperone DnaK	-
JW961_RS03095	637839..638969	+	1131	WP_024705022.1	molecular chaperone DnaJ	-
JW961_RS03100	639074..639226	-	153	WP_046082123.1	type I toxin-antitoxin system toxin MokC	Toxin
-	639275..639332	+	58	-	-	Antitoxin
JW961_RS03105	639767..640933	+	1167	WP_046076806.1	Na+/H+ antiporter NhaA	-
JW961_RS03110	641001..641900	+	900	WP_000019049.1	transcriptional activator NhaR	-
JW961_RS03115	641996..642259	-	264	WP_001274021.1	30S ribosomal protein S20	-
JW961_RS03120	642362..642580	+	219	WP_223663094.1	DUF2575 domain-containing protein	-
JW961_RS03125	642588..643529	+	942	WP_000767324.1	bifunctional riboflavin kinase/FAD synthetase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (7-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5511.59 Da
• Isoelectric Point: 7.1312

>T194727 WP_046082123.1 NZ_CP070951:c639226-639074 [Escherichia fergusonii]
MKQHKAIIVALIVICITAVVVALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T194727 NZ_CP093940:4531913-4532488 [Pseudomonas sp. I3-I5]
ATGAGGCACTCACCTTTTACAGTTATCTACGACGCCTGCGTGCTTTATCCAGCACCATTGCGTGACCTATTGATGCATCT
GGCTCTGACTGGCGTGTATCGCGCGCGCGGGTCCGAGCAAATCCACGATGAATGGACACGAAACGTGTTAAGAAGCCGTC
CCGACGTGTCAGAAACACAGCTTTATCGCACAGTCGGACTCATGAATCGGGCGATTCCTGACTCTCTGGTAAATGACTAC
GAGCCACTTGTGCAGGGGCTTGACCTTCCAGACGAAGACGATAGACACGTCTTGGCAGCAGCGATCAAATGTGGCGCCTC
GGTGATTGTCACGTACAACCTCAAAGATTTTCCGACCGAGATTCTGAAACGTTTTGAGATCGAGGCGTTGCATCCCGATG
TATTCCTCTCCGACATCTGGGACCTTGATCACGCAGCTGTGCTCAAGGCCGTCCAGAAGCAGCGCGCAGCCCTTAACAAT
CCGGTTTACTCACCCCGCGAGCTGCTGGACATCCTCCTCAAGCAGCGGCTCCCAGAGACCGTCAAGCACCTCTCGAACCA
CGAGCTGCTGATCTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT194727 NZ_CP070951:639275-639332 [Escherichia fergusonii]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Antitoxin