Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4590874..4591476 Replicon chromosome
Accession NZ_CP070920
Organism Escherichia coli strain 40EC

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag JR909_RS22135 Protein ID WP_205899241.1
Coordinates 4591165..4591476 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JR909_RS22130 Protein ID WP_000356397.1
Coordinates 4590874..4591164 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JR909_RS22105 4586800..4587702 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
JR909_RS22110 4587699..4588334 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
JR909_RS22115 4588331..4589260 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
JR909_RS22120 4589590..4589832 - 243 WP_001086388.1 hypothetical protein -
JR909_RS22125 4590051..4590269 - 219 WP_001297075.1 ribbon-helix-helix domain-containing protein -
JR909_RS22130 4590874..4591164 - 291 WP_000356397.1 helix-turn-helix domain-containing protein Antitoxin
JR909_RS22135 4591165..4591476 - 312 WP_205899241.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JR909_RS22140 4591705..4592613 + 909 WP_001162704.1 alpha/beta hydrolase -
JR909_RS22145 4592677..4593618 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
JR909_RS22150 4593663..4594100 - 438 WP_000560983.1 D-tyrosyl-tRNA(Tyr) deacylase -
JR909_RS22155 4594097..4594969 - 873 WP_000920762.1 virulence factor BrkB family protein -
JR909_RS22160 4594963..4595562 - 600 WP_001295269.1 glucose-1-phosphatase -
JR909_RS22165 4595661..4596446 - 786 WP_000059678.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12189.21 Da        Isoelectric Point: 10.0241

>T194685 WP_205899241.1 NZ_CP070920:c4591476-4591165 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDNLSPQEKAMLRLLNTRW

Download         Length: 312 bp

>T194685 NZ_CP093921:c63678-63376 [Escherichia coli]
ATGACCAAAAAAATTAACATAAAGGATTTCAGGGATGCGTGGCTTGATGATTTTTTTGAATTTTCAACACCACATAGAAA
GATACCTCCTGATATTCATATGACATTGTCACGGAAGTTGGACATTATCAATGCCGCAACTACCTGTAAGGATTTAAGAT
CACCACCAGGTAATCGGTATGAGGAACTGTCAGGGAAGCTAAATGGCTATTCATCAGTAAGGGTGAATAAGCAATATAGG
TTAATTTTTAAGTGGGTTAACGGAAAGGCCGAGGACTTGTATCTCGACCCTCACAAATACTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT194685 WP_000356397.1 NZ_CP070920:c4591164-4590874 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp

>AT194685 NZ_CP093921:c63305-62967 [Escherichia coli]
ATGAAACAGGCAACCAGAAAACCGACGACCGTAGGTGATATCCTGCTGTACGAATACCTGGAGCCGTTAGAGCTGAAGAT
CAACGAGTTAGCAGAAATACTTCATGTTCATCGTAACACCGTAAGTGCTCTTGTTAATAATAATCGTAAGCTAACGATGG
ATATGGCATATCGCCTGGCAAAAGCATTCGATACTTCTGTAGATTTTTGGATTAATCTTCAGACCGCAGTAGATCTGTGG
GAAGTCGAAAATGATATGCGCGTTCAGGAAGAGTTAAGTCGTATCAATACTGCTGAAAAATTTATTTCTCAGCGGAACCT
GAATAAAAAAGCAGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References