Detailed information of TA system TA194533

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1969512..1969770
• Replicon: chromosome
• Accession: NZ_CP070873
• Organism: Escherichia fergusonii strain EF91

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: JW972_RS09580
• Protein ID: WP_000809168.1
• Coordinates: 1969512..1969664 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	1969713..1969770 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JW972_RS09560	1964577..1965164	+	588	WP_002431696.1	molybdopterin adenylyltransferase	-
JW972_RS09565	1965198..1965764	-	567	WP_000528529.1	acetate uptake transporter	-
JW972_RS09570	1966272..1968188	+	1917	WP_000516135.1	molecular chaperone DnaK	-
JW972_RS09575	1968277..1969407	+	1131	WP_001470960.1	molecular chaperone DnaJ	-
JW972_RS09580	1969512..1969664	-	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
-	1969713..1969770	+	58	-	-	Antitoxin
JW972_RS09585	1970206..1971372	+	1167	WP_000681374.1	Na+/H+ antiporter NhaA	-
JW972_RS09590	1971440..1972339	+	900	WP_000019050.1	transcriptional activator NhaR	-
JW972_RS09595	1972435..1972698	-	264	WP_001274021.1	30S ribosomal protein S20	-
JW972_RS09600	1972801..1973019	+	219	WP_001353471.1	DUF2575 family protein	-
JW972_RS09605	1973027..1973968	+	942	WP_104918205.1	bifunctional riboflavin kinase/FAD synthetase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T194533 WP_000809168.1 NZ_CP070873:c1969664-1969512 [Escherichia fergusonii]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T194533 NZ_CP093548:2459538-2460431 [Escherichia coli]
ATGCCTGAATTAACATCATTATTTCCTGACGTTGCCGATGCACTGGATATTGAATCTGTCGCTATCGTCGAAAAAGATTA
TTTTGTGGTTGATCTTTTAAGATTATTAAAAGAAATAAAACCAGAAACACATACTCTCGTGTTTGCAGGTAGTACCGCAT
TATCAAAAGCAGGTATCTCGCTAAACAGAATGTCAGAAGATATTGATATAAAGCTCGTGCCAACAGAGAACTTTATGCAA
AATGGCAGAGACAAGAGAAGAAAAATTCGCAAGGAAATCGTGCAAATAATCACGGATGTTATTCATAATTCTGACATTTT
CAGCTTGGATAATGAAAACGCCCGTATAACACGTGATGAGTATCGTTATAACGAAATCTCGGTACGTTATCCCCAGACAT
TTGCACAAGTCCCCTGTCTTCGTCCATTTATTAAGCTGGAGTTGATGGAAAGCACTCTGCTGGAACATCCGGAAAGCAGA
GATATTTATTCCCTTGTAACGGAGTTAACGGGTAAAGGTACACCTATAACAGCATTCCCCTGTGCCACCATTTTATCCAC
TCAGGCTGAAAAGCTCATCTCCATGATGCGAAGAACAGCAGCACATCTTCGTAATCCCGAACAACAGGATGATGAGTTTC
TGGTACGTCACATTTATGACAACTACTGCATTGTCAGGGAAAAAGGTGTGAATGTTCCTGTATTGAAAAATTTTGTTCAG
ATATGTATTCAACAGGATATTGAACGCTATGGTAACCAGTACCCACAATTTTGTAGCTCACCAGTTGATGAACTTAAGAA
AGGGCTGGATGCACTCCGGGATTATCCTGTACACAAATTGCGCTTTCAACGATTTGTTAACCCGATGGTATTTGGTAATA
CACAGATTAACTAG

Antitoxin

Nucleotide

• Length: 58 bp

>AT194533 NZ_CP070873:1969713-1969770 [Escherichia fergusonii]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin