Detailed information of TA system TA194529

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1034787..1035044
• Replicon: chromosome
• Accession: NZ_CP070873
• Organism: Escherichia fergusonii strain EF91

Toxin (Protein)

• Gene name: hokA
• Uniprot ID: -
• Locus tag: JW972_RS04975
• Protein ID: WP_001135723.1
• Coordinates: 1034787..1034939 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokA
Locus tag	-
Coordinates	1034996..1035044 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JW972_RS04945	1030652..1031362	-	711	WP_000190514.1	DUF3053 domain-containing protein	-
JW972_RS04950	1031800..1033170	+	1371	WP_000184983.1	MFS transporter	-
JW972_RS04955	1033420..1033710	+	291	WP_000455800.1	HTH-type transcriptional regulator	-
JW972_RS04960	1033992..1034204	+	213	WP_000014594.1	RNA chaperone/antiterminator CspA	-
JW972_RS04965	1034258..1034629	-	372	WP_001037803.1	membrane protein insertion efficiency factor YidD	-
JW972_RS04970	1034739..1034810	+	72	WP_216665726.1	hypothetical protein	-
JW972_RS04975	1034787..1034939	-	153	WP_001135723.1	type I toxin-antitoxin system toxin HokA	Toxin
-	1034996..1035044	+	49	-	-	Antitoxin
JW972_RS04980	1035239..1035598	-	360	WP_148047754.1	hypothetical protein	-
JW972_RS04985	1035667..1037736	-	2070	WP_001291786.1	glycine--tRNA ligase subunit beta	-
JW972_RS04990	1037746..1038657	-	912	WP_001168544.1	glycine--tRNA ligase subunit alpha	-
JW972_RS04995	1038753..1039052	-	300	WP_223666502.1	YsaB family lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5899.14 Da
• Isoelectric Point: 6.9160

>T194529 WP_001135723.1 NZ_CP070873:c1034939-1034787 [Escherichia fergusonii]
MPQKYGLLSLIVICFTLLFFTWMIRDSLCELHIKQESYELAAFLACKLKE

Nucleotide

• Length: 153 bp

>T194529 NZ_CP093548:c2073477-2073166 [Escherichia coli]
ATGCACATCATTTCGAAAGCGCCATTTGAAGAGTGTGCGCGCAAATATCCTAACGACGCTCTGGCTCTATACTCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACACCAGAAGAAATGCGAACGGCGTTTCCCAACCTCGACAATTTTAGATATC
GCAACAAATGGTACGTTCTGGATGTCGGCGGGAACAATCTTAGGGTTATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACGAATCACGCAGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA

Antitoxin

Nucleotide

• Length: 49 bp

>AT194529 NZ_CP070873:1034996-1035044 [Escherichia fergusonii]
GCATAGAGGGGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Structures

Antitoxin