Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4453937..4454604 Replicon chromosome
Accession NZ_CP070619
Organism Rhodococcus sp. R79

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag JWS13_RS25660 Protein ID WP_206008166.1
Coordinates 4453937..4454293 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name HigA2 Uniprot ID -
Locus tag JWS13_RS25665 Protein ID WP_160097883.1
Coordinates 4454299..4454604 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JWS13_RS25625 4449092..4449760 - 669 WP_206008160.1 SDR family oxidoreductase -
JWS13_RS25630 4449816..4450220 - 405 WP_206008161.1 TIGR03668 family PPOX class F420-dependent oxidoreductase -
JWS13_RS25635 4450220..4450801 - 582 WP_206008162.1 hypothetical protein -
JWS13_RS25640 4450849..4451469 - 621 WP_206008163.1 LysE family transporter -
JWS13_RS25645 4451542..4452417 + 876 WP_206008164.1 ArgP/LysG family DNA-binding transcriptional regulator -
JWS13_RS25650 4452463..4453461 + 999 WP_206011721.1 PHP domain-containing protein -
JWS13_RS25655 4453499..4453804 - 306 WP_206008165.1 hypothetical protein -
JWS13_RS25660 4453937..4454293 + 357 WP_206008166.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JWS13_RS25665 4454299..4454604 + 306 WP_160097883.1 helix-turn-helix domain-containing protein Antitoxin
JWS13_RS25670 4455072..4455965 + 894 WP_206008167.1 SAM-dependent methyltransferase -
JWS13_RS25675 4455967..4456776 - 810 WP_206008168.1 MBL fold metallo-hydrolase -
JWS13_RS25680 4456833..4457600 - 768 WP_206008169.1 thiazole synthase -
JWS13_RS25685 4457813..4458028 + 216 WP_206008170.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-108)

Antitoxin

HigA2-like, helix-turn-helix domain

(32-92)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13265.20 Da        Isoelectric Point: 7.2054

>T194511 WP_206008166.1 NZ_CP070619:4453937-4454293 [Rhodococcus sp. R79]
VGQWTVEVGLVEEWLLALDQSSYEQVVAALELLADRGPQLGRPLVDTVKASRHKNMKELRPGSSGRSELRVLFAFDPERK
AILLVAGNKAGRWKSWYKVNIPIADDRFAAHLEELEGR

Download         Length: 357 bp

>T194511 NZ_CP093536:87499-87843 [Ralstonia pseudosolanacearum]
ATGGATGCTACCTTTATCGAGTTGCCGCCTTTTCAGAGGCTGCGGGAGCACTATCTCTCGGACGACGAGTACCGAGCGCT
CCAGCAGGAACTGCTGGCCCGGCCGGACGCCGGCGACGTCATCAAGGGGACAGGTGGCCTACGCAAGCTGCGATTTTCGG
ACAAGCGGCGCGGCAAAGGTAAGCGCGGCGGTCTGCGCGTGATTTACTACCACTGGGATGGAGGCGGCCAATTCTGGATG
TTTGTCGTCTACGACAAGGGCGAGGCGGACGACCTTTCCAGCGACGAGCGCAAAGTGCTGGCACGGCTGCTGGAGCAGGA
AGTCAAGGCAAGGAGTGAGCGATGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11487.08 Da        Isoelectric Point: 5.7737

>AT194511 WP_160097883.1 NZ_CP070619:4454299-4454604 [Rhodococcus sp. R79]
MAKSLEQMLAERPVDRGAVDAHKARMIDEVRAYRLQELRESVAMTQKQLAERLGVGQNRVSNIEHGDLERVQIDTLRRYV
EAVGGALRVEVELGDERFQIA

Download         Length: 306 bp

>AT194511 NZ_CP093536:87840-88151 [Ralstonia pseudosolanacearum]
ATGAAACGGAACCTGTTTGCTGAGTTGAAGGAGGGGATGGATGCGCTTGCCGCAGAGCGCGAAGGAAAGATGACCCTTCG
CAAGGTGAAGGTCCGCGTGCTCCAGCCGCTTGACGTGACAGCCGAAGAAATCAAGGCCGTTCGCGCAGCGGCACATGCTT
CACAGGCTGTCATGGCACGTCGACTGCGCGTCAATGTGCGCACCTACCAGAACTGGGAACAAGGAACCGCCAAACCGAAC
ACCCAGGCGGCTGTGTTGATCAAGCTCGTCGAGAAGCATCCGGAAACGTTGCAGATGCTGGAAGCGCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References