Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2966914..2967416 Replicon chromosome
Accession NZ_CP070609
Organism Rhodococcus koreensis strain R85

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2A3FX41
Locus tag JWS14_RS13720 Protein ID WP_072937239.1
Coordinates 2967159..2967416 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2A3FWL4
Locus tag JWS14_RS13715 Protein ID WP_072937240.1
Coordinates 2966914..2967162 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JWS14_RS13685 2962451..2962843 + 393 WP_072937246.1 tautomerase family protein -
JWS14_RS13690 2963010..2963294 - 285 WP_072937245.1 hypothetical protein -
JWS14_RS13695 2963584..2964279 + 696 WP_095862244.1 response regulator transcription factor -
JWS14_RS13700 2964257..2964676 - 420 WP_095862243.1 response regulator -
JWS14_RS13705 2964731..2966272 - 1542 WP_095862242.1 DUF4118 domain-containing protein -
JWS14_RS13710 2966529..2966762 + 234 WP_206013510.1 hypothetical protein -
JWS14_RS13715 2966914..2967162 + 249 WP_072937240.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
JWS14_RS13720 2967159..2967416 + 258 WP_072937239.1 Txe/YoeB family addiction module toxin Toxin
JWS14_RS13725 2967413..2968012 - 600 WP_072937238.1 hypothetical protein -
JWS14_RS13730 2968009..2968671 - 663 WP_206013511.1 TetR family transcriptional regulator -
JWS14_RS13735 2968761..2969903 - 1143 WP_072937236.1 acyl-CoA dehydrogenase family protein -
JWS14_RS13740 2969916..2971109 - 1194 WP_072937235.1 acyl-CoA dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10233.52 Da        Isoelectric Point: 7.3969

>T194505 WP_072937239.1 NZ_CP070609:2967159-2967416 [Rhodococcus koreensis]
VNTAFTDDGWDDYTYWLTNDRKVLAKINALIKDIKRSPYQGIGKPERLRHMEDNVWSRRITHEHRLVYVIVDDTVVIQQA
RYHYD

Download         Length: 258 bp

>T194505 NZ_CP093528:4257144-4257566 [Shinella zoogloeoides]
ATGATCCTCCTCGATACCAATGTCGTATCGGAGGCGATGAAGCCCGCTCCCGACGATGCCGTGCGCGCATGGCTCGACGA
ACAGGCGGCGGAAACACTCTTTCTCTCCAGCGTCACCATCGCCGAGCTGATGTTCGGCATCGGCGCGCTCCCCGAGGGCA
AGCGCAAGGAGCGTCTCACCGAAGCCCTGGATGGGGTGATGGAACTGTTCGCAGACCGCGTCCTCCCGTTCGATGTCGAT
GCTGCGCGCCGCTATGCGGATCTCGCCGTCAAAGCCCGAACGGCCGGGAAAGGCTTCCCTACTCCCGACGGCTATATCGC
GGCGATCGCAGCCGCCAAGGGCTTTGCCGTCGCCACGCGCGACAACAGCGCATTCGAGGCCGCGAATGTCACGGTCATCG
ATCCCTGGAAGGCCGGGCGCTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9142.24 Da        Isoelectric Point: 4.7672

>AT194505 WP_072937240.1 NZ_CP070609:2966914-2967162 [Rhodococcus koreensis]
MSAITATDARKNLFGLVSQVNEDHTPVEIVSKNGNAVLISKDDYDSIMETAYLLSSPANARRLLRSLEATRRGEYTDREL
IE

Download         Length: 249 bp

>AT194505 NZ_CP093528:4256893-4257147 [Shinella zoogloeoides]
ATGCCCGCAGTCACGATCAGGAATCTGTCCGACGCGACGCATCGCGCCCTCAAGGTGCGGGCGGCGCAGCACGGCCGCAG
CGCCGAAGCGGAAATGCGCGACATCCTCGAAATGGCTGTCCGCCCCGATACGCGCCTCCGGCTCGGCACGGCGCTCGCGG
AACGCAGCCGTCGCCTTGGCTTGACCAATGAGGATGTCGAGGCCCTCGACCAGGCGCGTGACAAGGCGCCCGCCAAGCCG
ATGAGCTTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A3FX41

Antitoxin

Source ID Structure
AlphaFold DB A0A2A3FWL4

References