Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
Location | 30331..30988 | Replicon | plasmid pA4411_IncC |
Accession | NZ_CP070596 | ||
Organism | Klebsiella pneumoniae strain KPA4411 |
Toxin (Protein)
Gene name | higB | Uniprot ID | U3PDC3 |
Locus tag | JW306_RS01695 | Protein ID | WP_000270043.1 |
Coordinates | 30331..30681 (+) | Length | 117 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | JW306_RS01700 | Protein ID | WP_000124640.1 |
Coordinates | 30686..30988 (+) | Length | 101 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JW306_RS01660 | 26805..27302 | - | 498 | WP_000062185.1 | hypothetical protein | - |
JW306_RS01665 | 27305..27793 | - | 489 | WP_001273096.1 | DUF1643 domain-containing protein | - |
JW306_RS01670 | 27890..28225 | + | 336 | WP_000683476.1 | hypothetical protein | - |
JW306_RS01675 | 28240..28710 | - | 471 | WP_001281821.1 | hypothetical protein | - |
JW306_RS01680 | 28703..29074 | - | 372 | WP_000516916.1 | hypothetical protein | - |
JW306_RS01685 | 29085..29279 | - | 195 | WP_000343597.1 | hypothetical protein | - |
JW306_RS01690 | 29620..30168 | - | 549 | WP_001061574.1 | transcriptional regulator | - |
JW306_RS01695 | 30331..30681 | + | 351 | WP_000270043.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
JW306_RS01700 | 30686..30988 | + | 303 | WP_000124640.1 | XRE family transcriptional regulator | Antitoxin |
JW306_RS01705 | 31015..31308 | - | 294 | WP_001239997.1 | chromosome segregation protein ParM | - |
JW306_RS01710 | 31396..31566 | - | 171 | Protein_36 | HU family DNA-binding protein | - |
JW306_RS01715 | 31647..32402 | - | 756 | WP_000194037.1 | IS21-like element ISAs29 family helper ATPase IstB | - |
JW306_RS01720 | 32417..33958 | - | 1542 | WP_041206683.1 | IS21 family transposase | - |
JW306_RS01725 | 34179..34286 | - | 108 | Protein_39 | HU family DNA-binding protein | - |
JW306_RS01730 | 34344..34871 | - | 528 | WP_001236377.1 | thermonuclease family protein | - |
JW306_RS01735 | 35102..35959 | - | 858 | WP_001167032.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Conjugative plasmid | sul2 / aac(6')-Im / aph(2'')-Ib | - | 1..102008 | 102008 | |
- | flank | IS/Tn | - | - | 25309..26013 | 704 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 13328.21 Da Isoelectric Point: 5.2421
>T194467 WP_000270043.1 NZ_CP070596:30331-30681 [Klebsiella pneumoniae]
MWVIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPIRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE
MWVIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPIRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE
Download Length: 351 bp
>T194467 NZ_CP093495:4017027-4017245 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA
Antitoxin
Download Length: 101 a.a. Molecular weight: 11006.73 Da Isoelectric Point: 7.2036
>AT194467 WP_000124640.1 NZ_CP070596:30686-30988 [Klebsiella pneumoniae]
MARTLDQMLATEKPEVVAKAQKAATEMLLNIHLAELRDRMNLTQGEIAASLGVRQPTVSEMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFAV
MARTLDQMLATEKPEVVAKAQKAATEMLLNIHLAELRDRMNLTQGEIAASLGVRQPTVSEMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFAV
Download Length: 303 bp
>AT194467 NZ_CP093495:4016626-4017000 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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