Detailed information of TA system TA194444

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 1904983..1905204
• Replicon: chromosome
• Accession: NZ_CP070593
• Organism: Escherichia coli strain ESC53083

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: A0A1U9U3P9
• Locus tag: JW305_RS10715
• Protein ID: WP_001531632.1
• Coordinates: 1904983..1905090 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	1905138..1905204 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JW305_RS10690	1900827..1901909	+	1083	WP_000804726.1	peptide chain release factor 1	-
JW305_RS10695	1901909..1902742	+	834	WP_000456450.1	peptide chain release factor N(5)-glutamine methyltransferase	-
JW305_RS10700	1902739..1903131	+	393	WP_000200375.1	invasion regulator SirB2	-
JW305_RS10705	1903135..1903944	+	810	WP_001257044.1	invasion regulator SirB1	-
JW305_RS10710	1903980..1904834	+	855	WP_000811065.1	3-deoxy-8-phosphooctulonate synthase	-
JW305_RS10715	1904983..1905090	-	108	WP_001531632.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	1905138..1905204	+	67	NuclAT_10	-	Antitoxin
-	1905138..1905204	+	67	NuclAT_10	-	Antitoxin
-	1905138..1905204	+	67	NuclAT_10	-	Antitoxin
-	1905138..1905204	+	67	NuclAT_10	-	Antitoxin
-	1905138..1905204	+	67	NuclAT_5	-	Antitoxin
-	1905138..1905204	+	67	NuclAT_5	-	Antitoxin
-	1905138..1905204	+	67	NuclAT_5	-	Antitoxin
-	1905138..1905204	+	67	NuclAT_5	-	Antitoxin
-	1905138..1905204	+	67	NuclAT_6	-	Antitoxin
-	1905138..1905204	+	67	NuclAT_6	-	Antitoxin
-	1905138..1905204	+	67	NuclAT_6	-	Antitoxin
-	1905138..1905204	+	67	NuclAT_6	-	Antitoxin
-	1905138..1905204	+	67	NuclAT_7	-	Antitoxin
-	1905138..1905204	+	67	NuclAT_7	-	Antitoxin
-	1905138..1905204	+	67	NuclAT_7	-	Antitoxin
-	1905138..1905204	+	67	NuclAT_7	-	Antitoxin
-	1905138..1905204	+	67	NuclAT_8	-	Antitoxin
-	1905138..1905204	+	67	NuclAT_8	-	Antitoxin
-	1905138..1905204	+	67	NuclAT_8	-	Antitoxin
-	1905138..1905204	+	67	NuclAT_8	-	Antitoxin
-	1905138..1905204	+	67	NuclAT_9	-	Antitoxin
-	1905138..1905204	+	67	NuclAT_9	-	Antitoxin
-	1905138..1905204	+	67	NuclAT_9	-	Antitoxin
-	1905138..1905204	+	67	NuclAT_9	-	Antitoxin
-	1905140..1905203	+	64	NuclAT_12	-	-
-	1905140..1905203	+	64	NuclAT_12	-	-
-	1905140..1905203	+	64	NuclAT_12	-	-
-	1905140..1905203	+	64	NuclAT_12	-	-
-	1905140..1905203	+	64	NuclAT_13	-	-
-	1905140..1905203	+	64	NuclAT_13	-	-
-	1905140..1905203	+	64	NuclAT_13	-	-
-	1905140..1905203	+	64	NuclAT_13	-	-
-	1905140..1905203	+	64	NuclAT_14	-	-
-	1905140..1905203	+	64	NuclAT_14	-	-
-	1905140..1905203	+	64	NuclAT_14	-	-
-	1905140..1905203	+	64	NuclAT_14	-	-
-	1905140..1905203	+	64	NuclAT_15	-	-
-	1905140..1905203	+	64	NuclAT_15	-	-
-	1905140..1905203	+	64	NuclAT_15	-	-
-	1905140..1905203	+	64	NuclAT_15	-	-
-	1905140..1905203	+	64	NuclAT_16	-	-
-	1905140..1905203	+	64	NuclAT_16	-	-
-	1905140..1905203	+	64	NuclAT_16	-	-
-	1905140..1905203	+	64	NuclAT_16	-	-
-	1905140..1905203	+	64	NuclAT_17	-	-
-	1905140..1905203	+	64	NuclAT_17	-	-
-	1905140..1905203	+	64	NuclAT_17	-	-
-	1905140..1905203	+	64	NuclAT_17	-	-
-	1905140..1905205	+	66	NuclAT_18	-	-
-	1905140..1905205	+	66	NuclAT_18	-	-
-	1905140..1905205	+	66	NuclAT_18	-	-
-	1905140..1905205	+	66	NuclAT_18	-	-
-	1905140..1905205	+	66	NuclAT_19	-	-
-	1905140..1905205	+	66	NuclAT_19	-	-
-	1905140..1905205	+	66	NuclAT_19	-	-
-	1905140..1905205	+	66	NuclAT_19	-	-
-	1905140..1905205	+	66	NuclAT_20	-	-
-	1905140..1905205	+	66	NuclAT_20	-	-
-	1905140..1905205	+	66	NuclAT_20	-	-
-	1905140..1905205	+	66	NuclAT_20	-	-
-	1905140..1905205	+	66	NuclAT_21	-	-
-	1905140..1905205	+	66	NuclAT_21	-	-
-	1905140..1905205	+	66	NuclAT_21	-	-
-	1905140..1905205	+	66	NuclAT_21	-	-
-	1905140..1905205	+	66	NuclAT_22	-	-
-	1905140..1905205	+	66	NuclAT_22	-	-
-	1905140..1905205	+	66	NuclAT_22	-	-
-	1905140..1905205	+	66	NuclAT_22	-	-
-	1905140..1905205	+	66	NuclAT_23	-	-
-	1905140..1905205	+	66	NuclAT_23	-	-
-	1905140..1905205	+	66	NuclAT_23	-	-
-	1905140..1905205	+	66	NuclAT_23	-	-
JW305_RS10720	1905495..1906595	-	1101	WP_000063608.1	sodium-potassium/proton antiporter ChaA	-
JW305_RS10725	1906865..1907104	+	240	WP_000120702.1	putative cation transport regulator ChaB	-
JW305_RS10730	1907253..1907948	+	696	WP_001295621.1	glutathione-specific gamma-glutamylcyclotransferase	-
JW305_RS10735	1907992..1908345	-	354	WP_001169659.1	DsrE/F sulfur relay family protein YchN	-
JW305_RS10740	1908530..1909924	+	1395	WP_000086187.1	inverse autotransporter invasin YchO	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4040.89 Da
• Isoelectric Point: 12.5163

>T194444 WP_001531632.1 NZ_CP070593:c1905090-1904983 [Escherichia coli]
MTLAQFAMIFWHNLAAPILAGIITAVIVSWWRNRK

Nucleotide

• Length: 108 bp

>T194444 NZ_CP093486:c4557787-4557254 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Nucleotide

• Length: 67 bp

>AT194444 NZ_CP070593:1905138-1905204 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• AlphaFold DB: A0A1U9U3P9

Antitoxin