Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3894402..3894999 Replicon chromosome
Accession NZ_CP070528
Organism Klebsiella pneumoniae strain KP47693

Toxin (Protein)


Gene name higB Uniprot ID R4YIC5
Locus tag JW292_RS19615 Protein ID WP_004142563.1
Coordinates 3894682..3894999 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID R4YH91
Locus tag JW292_RS19610 Protein ID WP_004142561.1
Coordinates 3894402..3894689 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JW292_RS19575 3889706..3889954 + 249 WP_002893037.1 DUF1158 domain-containing protein -
JW292_RS19580 3889972..3890283 - 312 WP_204779915.1 RamA family antibiotic efflux transcriptional regulator -
JW292_RS19585 3890341..3891038 + 698 Protein_3710 IS1 family transposase -
JW292_RS19590 3891121..3892236 - 1116 Protein_3711 MBL fold metallo-hydrolase -
JW292_RS19595 3892415..3892996 + 582 WP_032419262.1 TetR/AcrR family transcriptional regulator -
JW292_RS19600 3892996..3893364 + 369 WP_004142557.1 MmcQ/YjbR family DNA-binding protein -
JW292_RS19605 3893484..3894137 + 654 WP_032419263.1 oxygen-insensitive NAD(P)H nitroreductase -
JW292_RS19610 3894402..3894689 - 288 WP_004142561.1 helix-turn-helix transcriptional regulator Antitoxin
JW292_RS19615 3894682..3894999 - 318 WP_004142563.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JW292_RS19620 3895184..3896227 - 1044 WP_032419264.1 DUF2157 domain-containing protein -
JW292_RS19625 3896894..3897760 - 867 WP_032419265.1 helix-turn-helix transcriptional regulator -
JW292_RS19630 3897869..3899296 + 1428 WP_004176980.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.39 Da        Isoelectric Point: 11.2767

>T194276 WP_004142563.1 NZ_CP070528:c3894999-3894682 [Klebsiella pneumoniae]
MFRLVVHVDVKKELQALPPIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

>T194276 NZ_CP093402:3836553-3836810 [Salmonella enterica subsp. enterica serovar Agona]
ATGAATGCCTCCGGCGTCAGCGTCCGCCACATCAACAGCGAAACCTGTATAACCACCTGTTACTCACAAATCCCCAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTGAGACCGGGCGCAGCGTGACGGTGAAGATTTCACAGGGGTGTA
TTGTGCTAATGGCGGACGGTAACGAGGTGCAGAAGCTGTGCGAACAGCTTTATCAGGCTGAACGGGTGGTTAAGGGGTTG
AAGGATGTACTGGTTTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10771.46 Da        Isoelectric Point: 10.2212

>AT194276 WP_004142561.1 NZ_CP070528:c3894689-3894402 [Klebsiella pneumoniae]
MSKKIIDWDTLKTELLGQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp

>AT194276 NZ_CP093402:c3836774-3836396 [Salmonella enterica subsp. enterica serovar Agona]
TTCAGCCTGATAAAGCTGTTCGCACAGCTTCTGCACCTCGTTACCGTCCGCCATTAGCACAATACACCCCTGTGAAATCT
TCACCGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAG
TAACAGGTGGTTATACAGGTTTCGCTGTTGATGTGGCGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAA
TTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAGCGAGTATGGGCGCGACATCCTGGCACCGCGCC
CCCCTCTCCCCGGCCAGCACCGGGCGGTGATGAGCAACCGGCTACCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M5MXH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3DIQ1

References