Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 32703..33354 Replicon plasmid p46903_2
Accession NZ_CP070522
Organism Morganella morganii strain MM46903

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag JW291_RS00480 Protein ID WP_205448027.1
Coordinates 33004..33354 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JW291_RS00475 Protein ID WP_205448026.1
Coordinates 32703..33002 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JW291_RS00435 27855..28775 - 921 WP_205448017.1 hypothetical protein -
JW291_RS00440 29095..29313 + 219 WP_205448018.1 hypothetical protein -
JW291_RS00445 29331..29660 - 330 WP_205448019.1 hypothetical protein -
JW291_RS00450 29660..29908 - 249 WP_205448020.1 hypothetical protein -
JW291_RS00455 30276..30734 - 459 WP_205448022.1 hypothetical protein -
JW291_RS00460 30758..30934 - 177 WP_205448023.1 hypothetical protein -
JW291_RS00465 30942..31226 - 285 WP_205448024.1 CopG family transcriptional regulator -
JW291_RS00470 31327..31992 - 666 WP_205448025.1 AAA family ATPase -
JW291_RS00475 32703..33002 - 300 WP_205448026.1 XRE family transcriptional regulator Antitoxin
JW291_RS00480 33004..33354 - 351 WP_205448027.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JW291_RS00485 33752..34246 + 495 WP_205448028.1 hypothetical protein -
JW291_RS00490 34495..34806 + 312 WP_205448029.1 hypothetical protein -
JW291_RS00495 35813..36340 - 528 WP_205448081.1 hypothetical protein -
JW291_RS00500 36375..36845 - 471 WP_205448033.1 H-NS histone family protein -
JW291_RS00505 36856..37062 - 207 WP_205448037.1 hemolysin activation protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..38408 38408


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(15-87)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13489.39 Da        Isoelectric Point: 6.7221

>T194259 WP_205448027.1 NZ_CP070522:c33354-33004 [Morganella morganii]
MWDVITTERFDEWFLAQSDALRESVYEAMGVLEKFGPALGRPYVDTLNDSDFANMKELRIQHHGNPVRAFFAFDPSRRAI
VLCAGDKTGLNEKRFYKDMIKLADSEYRKHLAKLEK

Download         Length: 351 bp

>T194259 NZ_CP093400:c2643056-2642953 [Salmonella enterica subsp. enterica serovar Infantis]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10967.63 Da        Isoelectric Point: 5.8719

>AT194259 WP_205448026.1 NZ_CP070522:c33002-32703 [Morganella morganii]
MATYRELLAKESPEMQARVAERVEEASLQIALSALRDELNISQTELATIMGVKQPSVARMEQADNDPRLSTLKRYVKALG
GELSLDVTLPTGKRVAFHL

Download         Length: 300 bp

>AT194259 NZ_CP093400:2642951-2643094 [Salmonella enterica subsp. enterica serovar Infantis]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References