Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1257427..1258116 Replicon chromosome
Accession NZ_CP070520
Organism Klebsiella aerogenes strain EA46506

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag JW290_RS06500 Protein ID WP_042894575.1
Coordinates 1257427..1257723 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JW290_RS06505 Protein ID WP_032711784.1
Coordinates 1257781..1258116 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JW290_RS06490 1255454..1256611 + 1158 WP_205460619.1 porin OmpC -
JW290_RS06495 1256756..1257190 + 435 WP_020078631.1 universal stress protein UspF -
JW290_RS06500 1257427..1257723 + 297 WP_042894575.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JW290_RS06505 1257781..1258116 + 336 WP_032711784.1 HigA family addiction module antidote protein Antitoxin
JW290_RS06510 1258467..1259402 + 936 WP_205460620.1 tRNA 2-thiocytidine(32) synthetase TtcA -
JW290_RS06515 1259450..1260823 - 1374 WP_047042836.1 ATP-dependent RNA helicase DbpA -
JW290_RS06520 1261308..1262291 - 984 WP_015366313.1 zinc transporter ZntB -
JW290_RS06525 1262472..1262915 + 444 WP_020078629.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(7-96)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-84)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11554.16 Da        Isoelectric Point: 7.4629

>T194245 WP_042894575.1 NZ_CP070520:1257427-1257723 [Klebsiella aerogenes]
MQNHIGSFRDVWLEEFFLHSAPHKKIPPDIHTTLARKLDIINAAVTYLDLRSPPGNRYEELNGKLEGYSSIRINQQYRLI
FKWVDGKAEDLYLDPHKY

Download         Length: 297 bp

>T194245 NZ_CP093392:4512648-4512959 [Salmonella enterica]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTCTCCCATGCCGAATATGACAAACTGACCGCATATTATCGGGGTAATAAAGAATGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12694.53 Da        Isoelectric Point: 7.2045

>AT194245 WP_032711784.1 NZ_CP070520:1257781-1258116 [Klebsiella aerogenes]
MKQATRKPTTVGDILQFEYLEPLDLKINELAEMIHVHRNSVSALVNNNRKLTTDMAFRLSKAFNTTVDFWLNLQAAVDLW
EVENDTRAQEEFSRIVPASKFIASKADKKVA

Download         Length: 336 bp

>AT194245 NZ_CP093392:4512956-4513402 [Salmonella enterica]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAACCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTCAAACTACCAGCAGATGCCTTCATCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References