Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4631866..4632596 Replicon chromosome
Accession NZ_CP070508
Organism Serratia ureilytica strain AM923

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag IHE77_RS22120 Protein ID WP_206359529.1
Coordinates 4631866..4632177 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IHE77_RS22125 Protein ID WP_033644489.1
Coordinates 4632174..4632596 (+) Length 141 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IHE77_RS22090 (IHE77_22055) 4627180..4627905 + 726 WP_004937040.1 LPS export ABC transporter ATP-binding protein -
IHE77_RS22095 (IHE77_22060) 4627958..4629391 + 1434 WP_206359530.1 RNA polymerase factor sigma-54 -
IHE77_RS22100 (IHE77_22065) 4629415..4629702 + 288 WP_004937038.1 ribosome hibernation promoting factor -
IHE77_RS22105 (IHE77_22070) 4629858..4630319 + 462 WP_016930212.1 PTS IIA-like nitrogen regulatory protein PtsN -
IHE77_RS22110 (IHE77_22075) 4630447..4631301 + 855 WP_015379177.1 RNase adapter RapZ -
IHE77_RS22115 (IHE77_22080) 4631298..4631570 + 273 WP_004937034.1 PTS phosphocarrier protein NPr -
IHE77_RS22120 (IHE77_22085) 4631866..4632177 + 312 WP_206359529.1 type II toxin-antitoxin system HigB family toxin Toxin
IHE77_RS22125 (IHE77_22090) 4632174..4632596 + 423 WP_033644489.1 helix-turn-helix domain-containing protein Antitoxin
IHE77_RS22130 (IHE77_22095) 4632603..4634519 - 1917 WP_033644486.1 PRD domain-containing protein -
IHE77_RS22135 (IHE77_22100) 4634571..4635785 - 1215 WP_046687876.1 lactonase family protein -
IHE77_RS22140 (IHE77_22105) 4635873..4636613 - 741 WP_047573565.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(81-135)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.00 Da        Isoelectric Point: 9.9097

>T194239 WP_206359529.1 NZ_CP070508:4631866-4632177 [Serratia ureilytica]
MHIISGEPFNNATKQYPNEATALEAIYKALRRGEFRTPDELKALFPSLDRMKYKEKWWVIDVGGNHLRILFFASFETQKV
FIKHIVSHAEYDKLMQHYRRSSS

Download         Length: 312 bp

>T194239 NZ_CP093392:3430231-3430449 [Salmonella enterica]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 141 a.a.        Molecular weight: 15784.13 Da        Isoelectric Point: 5.2139

>AT194239 WP_033644489.1 NZ_CP070508:4632174-4632596 [Serratia ureilytica]
MITDAIKAADALLRAVPLLQGSHAQQDYREALELVEYLLENDERHPLIDMLAKKIAEYEDNSAEFTAFNQRIAQLPQGVA
ALRVLMEQHQLSQSDFEHEIGKKSLVNQILNGKRSLTIPHIMALAKRFNLPPALFLPEAD

Download         Length: 423 bp

>AT194239 NZ_CP093392:3429829-3430203 [Salmonella enterica]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References