Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4160584..4161236 Replicon chromosome
Accession NZ_CP070508
Organism Serratia ureilytica strain AM923

Toxin (Protein)


Gene name higB Uniprot ID A0A8E2QRT0
Locus tag IHE77_RS19920 Protein ID WP_033644839.1
Coordinates 4160584..4160928 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IHE77_RS19925 Protein ID WP_025304078.1
Coordinates 4160934..4161236 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IHE77_RS19910 (IHE77_19870) 4156927..4159185 - 2259 WP_241439483.1 molybdopterin guanine dinucleotide-containing S/N-oxide reductase -
IHE77_RS19915 (IHE77_19875) 4159406..4160425 + 1020 WP_033644840.1 HTH-type transcriptional regulator GalR -
IHE77_RS19920 (IHE77_19880) 4160584..4160928 + 345 WP_033644839.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IHE77_RS19925 (IHE77_19885) 4160934..4161236 + 303 WP_025304078.1 helix-turn-helix transcriptional regulator Antitoxin
IHE77_RS19930 (IHE77_19890) 4161264..4162526 - 1263 WP_033644838.1 diaminopimelate decarboxylase -
IHE77_RS19935 (IHE77_19895) 4162660..4163583 + 924 WP_046687734.1 LysR family transcriptional regulator -
IHE77_RS19940 (IHE77_19900) 4163611..4164519 - 909 WP_033644836.1 LysR family transcriptional regulator -
IHE77_RS19945 (IHE77_19905) 4164628..4165512 + 885 WP_069100465.1 MBL fold metallo-hydrolase -
IHE77_RS19950 (IHE77_19910) 4165581..4166228 + 648 WP_033644834.1 DsbA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-104)

Antitoxin

HigA2-like, helix-turn-helix domain

(29-89)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13339.39 Da        Isoelectric Point: 10.8296

>T194237 WP_033644839.1 NZ_CP070508:4160584-4160928 [Serratia ureilytica]
MWQVVTVERFDDWFLALNNAQQTSILAAIFKLQTFGPQLARPHADTLHFSEAARQLKELRVQHRGRPFRVFFAFDPQRQA
VLLCGGDKTGDKRFYQRMLPIAAMEFSHYLATRR

Download         Length: 345 bp

>T194237 NZ_CP093392:2064201-2064304 [Salmonella enterica]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11081.01 Da        Isoelectric Point: 10.3986

>AT194237 WP_025304078.1 NZ_CP070508:4160934-4161236 [Serratia ureilytica]
MAKPLSQLIDKLDPAVVAAARQKADKEIFELRLAMLREELAVSQVELAKRLGISQPSVANLEKRGSEIKLSSLKRYIEAM
GGTLSLDVQLPNGQHRRMTL

Download         Length: 303 bp

>AT194237 NZ_CP093392:c2064306-2064163 [Salmonella enterica]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References