Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 3594351..3595006 Replicon chromosome
Accession NZ_CP070506
Organism Pseudomonas sp. SDM007

Toxin (Protein)


Gene name higB Uniprot ID A0A1S1UXS8
Locus tag JTY93_RS15890 Protein ID WP_070995472.1
Coordinates 3594351..3594695 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1S1UVI2
Locus tag JTY93_RS15895 Protein ID WP_070995473.1
Coordinates 3594692..3595006 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JTY93_RS15880 3591109..3592641 + 1533 WP_205478268.1 NADH-quinone oxidoreductase subunit M -
JTY93_RS15885 3592649..3594112 + 1464 WP_065944419.1 NADH-quinone oxidoreductase subunit NuoN -
JTY93_RS15890 3594351..3594695 + 345 WP_070995472.1 toxin Toxin
JTY93_RS15895 3594692..3595006 + 315 WP_070995473.1 transcriptional regulator Antitoxin
JTY93_RS15900 3595080..3596818 - 1739 Protein_3126 carbohydrate ABC transporter substrate-binding protein -
JTY93_RS15905 3596992..3597264 - 273 WP_029293327.1 DUF2160 domain-containing protein -
JTY93_RS15910 3597275..3598075 - 801 WP_017735079.1 carbohydrate ABC transporter permease -
JTY93_RS15915 3598086..3598952 - 867 WP_029293322.1 sugar ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(41-100)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13470.41 Da        Isoelectric Point: 9.9080

>T194218 WP_070995472.1 NZ_CP070506:3594351-3594695 [Pseudomonas sp. SDM007]
MDALFIELPPFERYRKDYLTDELFHGFQQELMKNPEAGAVMEGTGGLRKLRFVDERRNKGKRGGLRVIYYWWSGGTQFWL
FTLYGKHEQSDLSPQHKKALKQLLDREINARGFT

Download         Length: 345 bp

>T194218 NZ_CP093391:194577-195062 [Salmonella enterica]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGC
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGCAGCGTCAACCATACAGAAGCGACAGGCAATCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCTGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11838.58 Da        Isoelectric Point: 10.5386

>AT194218 WP_070995473.1 NZ_CP070506:3594692-3595006 [Pseudomonas sp. SDM007]
MKRDIYSELVEGFDALANERQGKVTLRTHTVQQNKLAPLTAEDVIAVRQQLNLSRAVFAMYLRTNTRTLENWEQGRARPN
AQAATLIRLVSKFPDTVERLALLS

Download         Length: 315 bp

>AT194218 NZ_CP093391:194302-194589 [Salmonella enterica]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAGTCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCTGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1S1UXS8

Antitoxin

Source ID Structure
AlphaFold DB A0A1S1UVI2

References