Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/- |
Location | 3594351..3595006 | Replicon | chromosome |
Accession | NZ_CP070506 | ||
Organism | Pseudomonas sp. SDM007 |
Toxin (Protein)
Gene name | higB | Uniprot ID | A0A1S1UXS8 |
Locus tag | JTY93_RS15890 | Protein ID | WP_070995472.1 |
Coordinates | 3594351..3594695 (+) | Length | 115 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | A0A1S1UVI2 |
Locus tag | JTY93_RS15895 | Protein ID | WP_070995473.1 |
Coordinates | 3594692..3595006 (+) | Length | 105 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JTY93_RS15880 | 3591109..3592641 | + | 1533 | WP_205478268.1 | NADH-quinone oxidoreductase subunit M | - |
JTY93_RS15885 | 3592649..3594112 | + | 1464 | WP_065944419.1 | NADH-quinone oxidoreductase subunit NuoN | - |
JTY93_RS15890 | 3594351..3594695 | + | 345 | WP_070995472.1 | toxin | Toxin |
JTY93_RS15895 | 3594692..3595006 | + | 315 | WP_070995473.1 | transcriptional regulator | Antitoxin |
JTY93_RS15900 | 3595080..3596818 | - | 1739 | Protein_3126 | carbohydrate ABC transporter substrate-binding protein | - |
JTY93_RS15905 | 3596992..3597264 | - | 273 | WP_029293327.1 | DUF2160 domain-containing protein | - |
JTY93_RS15910 | 3597275..3598075 | - | 801 | WP_017735079.1 | carbohydrate ABC transporter permease | - |
JTY93_RS15915 | 3598086..3598952 | - | 867 | WP_029293322.1 | sugar ABC transporter permease | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 115 a.a. Molecular weight: 13470.41 Da Isoelectric Point: 9.9080
>T194218 WP_070995472.1 NZ_CP070506:3594351-3594695 [Pseudomonas sp. SDM007]
MDALFIELPPFERYRKDYLTDELFHGFQQELMKNPEAGAVMEGTGGLRKLRFVDERRNKGKRGGLRVIYYWWSGGTQFWL
FTLYGKHEQSDLSPQHKKALKQLLDREINARGFT
MDALFIELPPFERYRKDYLTDELFHGFQQELMKNPEAGAVMEGTGGLRKLRFVDERRNKGKRGGLRVIYYWWSGGTQFWL
FTLYGKHEQSDLSPQHKKALKQLLDREINARGFT
Download Length: 345 bp
>T194218 NZ_CP093391:194577-195062 [Salmonella enterica]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGC
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGCAGCGTCAACCATACAGAAGCGACAGGCAATCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCTGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGC
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGCAGCGTCAACCATACAGAAGCGACAGGCAATCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCTGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG
Antitoxin
Download Length: 105 a.a. Molecular weight: 11838.58 Da Isoelectric Point: 10.5386
>AT194218 WP_070995473.1 NZ_CP070506:3594692-3595006 [Pseudomonas sp. SDM007]
MKRDIYSELVEGFDALANERQGKVTLRTHTVQQNKLAPLTAEDVIAVRQQLNLSRAVFAMYLRTNTRTLENWEQGRARPN
AQAATLIRLVSKFPDTVERLALLS
MKRDIYSELVEGFDALANERQGKVTLRTHTVQQNKLAPLTAEDVIAVRQQLNLSRAVFAMYLRTNTRTLENWEQGRARPN
AQAATLIRLVSKFPDTVERLALLS
Download Length: 315 bp
>AT194218 NZ_CP093391:194302-194589 [Salmonella enterica]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAGTCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCTGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAGTCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCTGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1S1UXS8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1S1UVI2 |