Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 2642517..2643087 Replicon chromosome
Accession NZ_CP070501
Organism Agrococcus sp. Marseille-Q4369

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag JSQ78_RS13250 Protein ID WP_211448245.1
Coordinates 2642517..2642798 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JSQ78_RS13255 Protein ID WP_095796343.1
Coordinates 2642785..2643087 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JSQ78_RS13220 (JSQ78_13220) 2637718..2638800 - 1083 WP_211448236.1 Glu/Leu/Phe/Val dehydrogenase family protein -
JSQ78_RS13225 (JSQ78_13225) 2638978..2639712 - 735 WP_211448237.1 PRC-barrel domain-containing protein -
JSQ78_RS13230 (JSQ78_13230) 2639858..2640070 - 213 WP_211450651.1 acylphosphatase -
JSQ78_RS13235 (JSQ78_13235) 2640130..2640459 - 330 WP_211448239.1 hypothetical protein -
JSQ78_RS13240 (JSQ78_13240) 2640559..2641341 - 783 WP_211448241.1 YoaK family protein -
JSQ78_RS13245 (JSQ78_13245) 2641410..2642483 + 1074 WP_211448243.1 redox-regulated ATPase YchF -
JSQ78_RS13250 (JSQ78_13250) 2642517..2642798 + 282 WP_211448245.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JSQ78_RS13255 (JSQ78_13255) 2642785..2643087 + 303 WP_095796343.1 HigA family addiction module antitoxin Antitoxin
JSQ78_RS13260 (JSQ78_13260) 2643084..2643908 + 825 WP_211448246.1 alpha/beta hydrolase -
JSQ78_RS13275 (JSQ78_13275) 2646087..2646752 - 666 WP_211448248.1 arsenate reductase ArsC -
JSQ78_RS13280 (JSQ78_13280) 2646755..2647165 - 411 WP_211448249.1 arsenate reductase ArsC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(7-85)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10864.32 Da        Isoelectric Point: 10.4240

>T194201 WP_211448245.1 NZ_CP070501:2642517-2642798 [Agrococcus sp. Marseille-Q4369]
VIRSFGDKETERLWRRERVRSIDPRIHRVALRKLRQVGSAESIEDLRVPPGNRLEALKGDRAGQHSIRINDQWRICFVWT
AAGPEEVQIVDDH

Download         Length: 282 bp

>T194201 NZ_CP093386:4660978-4661289 [Salmonella enterica]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATACTATCGGGGTAATAAAGAATGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 10975.49 Da        Isoelectric Point: 4.8129

>AT194201 WP_095796343.1 NZ_CP070501:2642785-2643087 [Agrococcus sp. Marseille-Q4369]
MTTTDKIEPIHPGEVLMEDFIEGFGITQNKLAVSIGVPPRRINEIVHGKRGITADTALRLAKYFGTSAEFWINLQSHYEL
DRAEDAAGEQIAAIAPLQVA

Download         Length: 303 bp

>AT194201 NZ_CP093386:4661286-4661732 [Salmonella enterica]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAACCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTCAAACTACCAGCAGATGCCTTCATCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References