Detailed information of TA system TA194178

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 1467616..1468316
• Replicon: chromosome
• Accession: NZ_CP070494
• Organism: Methylomonas sp. EFPC1

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: JWZ98_RS06960
• Protein ID: WP_205453759.1
• Coordinates: 1467616..1467912 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: -
• Locus tag: JWZ98_RS06965
• Protein ID: WP_205454403.1
• Coordinates: 1467915..1468316 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JWZ98_RS06930	1463593..1464126	-	534	WP_205453753.1	helix-turn-helix domain-containing protein	-
JWZ98_RS06935	1464153..1464713	-	561	WP_205453754.1	hypothetical protein	-
JWZ98_RS06940	1464854..1465219	-	366	WP_205453755.1	hypothetical protein	-
JWZ98_RS06945	1465335..1466006	+	672	WP_205453756.1	SOS response-associated peptidase family protein	-
JWZ98_RS06950	1466295..1466708	-	414	WP_205453757.1	hypothetical protein	-
JWZ98_RS06955	1466819..1467130	-	312	WP_205453758.1	hypothetical protein	-
JWZ98_RS06960	1467616..1467912	+	297	WP_205453759.1	type II toxin-antitoxin system MqsR family toxin	Toxin
JWZ98_RS06965	1467915..1468316	+	402	WP_205454403.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
JWZ98_RS06970	1468754..1469515	-	762	WP_205453760.1	DNA adenine methylase	-
JWZ98_RS06975	1469481..1469672	-	192	WP_205453761.1	Com family DNA-binding transcriptional regulator	-
JWZ98_RS06980	1469807..1470565	-	759	WP_205453762.1	hypothetical protein	-
JWZ98_RS06985	1470651..1470869	-	219	WP_205453763.1	hypothetical protein	-
JWZ98_RS06990	1470970..1471422	-	453	WP_205453764.1	Mu transposase C-terminal domain-containing protein	-
JWZ98_RS06995	1471422..1471871	-	450	WP_205453765.1	hypothetical protein	-
JWZ98_RS07000	1471873..1472202	-	330	WP_205453766.1	helix-turn-helix domain-containing protein	-
JWZ98_RS07005	1472391..1473101	+	711	WP_205453767.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1463593..1477366	13773

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (5-97)

Antitoxin

• Antitoxin MqsA/HigA-2 (1-131)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 10842.63 Da
• Isoelectric Point: 8.0487

>T194178 WP_205453759.1 NZ_CP070494:1467616-1467912 [Methylomonas sp. EFPC1]
MEKQTPHCKLSVIRTLIADGKVRTTKSAREGAAALGFDFDGMLAVILGLTGADFYKSMTTHADHKVWQDVYRPKTLVGDV
YLKLTVVDDVLVVSFKEL

Nucleotide

• Length: 297 bp

>T194178 NZ_CP093376:379801-380217 [Cronobacter sakazakii]
GTGGTCCTGTGGCACTCTGATCTTCGCGTTTCATGGCGCTCGCAGTGGCTATCGCTGCTGCTGCACGGCGCCGTGGCCGT
TATTATTTTGCTGCTCCCCTGGCCGCTGCGGTATCTGCCCGTGTGGATGCTGTTGCTGTCTCTGGTGGTGTTTGACTGCG
TGCGTAGCCAACGGCGTATCAATGCGTTTCAGGGCGAGGTCAGCCTGACGGCTGATTATCAGCTACGCTGGCAGGGCGTT
GACTGGCAGATTTGCGCCACGCCCTGGATGTTGCGCAGCGGAATGATGCTGCGGCTGCGTCATCCGAAAACGACGCGCCG
CCATCATGTCTGGCTGGCGGCGGATAGCATGACGGAAGCGGAGTGGCGCGATTTGCGTCGCCTTCTGTTGCAACAGCCCA
TAGGCGACAAACGCTAA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14729.94 Da
• Isoelectric Point: 4.9927

>AT194178 WP_205454403.1 NZ_CP070494:1467915-1468316 [Methylomonas sp. EFPC1]
MKCPSCSAAELVKDTRDMPYTYKGESTIIPDVTGEFCPACDEVITDAEESRRTMALMMEFNKQVNASIVDPSFIASVRKK
LALDQKEASEIFGGGINAFSRYENGKTKPPLALVKLLKVLDRHPDLLDEVRTA

Nucleotide

• Length: 402 bp

>AT194178 NZ_CP093376:379554-379820 [Cronobacter sakazakii]
ATGGATATTAATAATAAAGCCCGTATTCATTGGGCATGTCGCAGAGGTATGCGCGAGCTGGATATTTCCATCATGCCTTT
CTTTGAATATGACTATGACTCCCTGAGCGACGAAGACAAATGCGTTTTTGTCCGCCTGCTGGAGTGTGACGATCCTGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCAGCTGATGCGGAGCTGGCGCGAATGGTGGAATTAATCCAGCAGCGGAAT
CAGGCACGTGGTCCTGTGGCACTCTGA