Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-YefM
Location 705473..705975 Replicon chromosome
Accession NZ_CP070494
Organism Methylomonas sp. EFPC1

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag JWZ98_RS03370 Protein ID WP_205453261.1
Coordinates 705712..705975 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag JWZ98_RS03365 Protein ID WP_205453260.1
Coordinates 705473..705715 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JWZ98_RS03340 700784..701794 + 1011 WP_205453257.1 tyrosine-type recombinase/integrase -
JWZ98_RS03345 702370..702933 + 564 WP_205453258.1 integrase arm-type DNA-binding domain-containing protein -
JWZ98_RS03350 702896..704140 + 1245 Protein_663 IS21 family transposase -
JWZ98_RS03355 704252..704896 + 645 WP_205450266.1 IS21-like element helper ATPase IstB -
JWZ98_RS03360 705102..705386 + 285 WP_205453259.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
JWZ98_RS03365 705473..705715 + 243 WP_205453260.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
JWZ98_RS03370 705712..705975 + 264 WP_205453261.1 Txe/YoeB family addiction module toxin Toxin
JWZ98_RS03375 706329..707471 + 1143 WP_205453262.1 radical SAM protein -
JWZ98_RS03380 707483..707785 + 303 WP_205453263.1 hypothetical protein -
JWZ98_RS03385 707834..708478 - 645 WP_205450266.1 IS21-like element helper ATPase IstB -
JWZ98_RS03390 708590..709471 - 882 WP_205454380.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 657213..705975 48762


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10184.74 Da        Isoelectric Point: 9.6964

>T194176 WP_205453261.1 NZ_CP070494:705712-705975 [Methylomonas sp. EFPC1]
VSWELIFTKQAQKDAKNLVSAGLKEKALQLLDILKNDPYQNPPAYEKLVGDLSGAYSRRINIQHRLVYQVLESERQVKIL
RMWSHYE

Download         Length: 264 bp

>T194176 NZ_CP093376:19746-20096 [Cronobacter sakazakii]
ATGATAAAACCGTTGTTTTGGGTCGGGCAGGCCAGAAAAGATCTTCAGGCGCTGCCGGAGGATGTACAGGATCTTTTTGG
CTATGCGCTTTATCTGGCGCAGCAGGGCAGACGCCATCCGCAGGCCAGGCCGCTTAAAGGTTTTGGCGGCGCGGGTGTGC
TTGAGGTCGTGGAGGATTATCAGGGGAATGCCTTTCGGGCGGTCTATACCGTTCGTCTGGGCGAGGCGATTTATGTCCTG
CATGTATTCCAGAAAAAATCCTCTTCCGGGATTGCCACGCCCCGCCCGGAGATGGAAAAAATTGAACAGCGACTTAAAGC
CGCGCAACGCCACGCCGGAGGGCTGAAATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8895.02 Da        Isoelectric Point: 4.2103

>AT194176 WP_205453260.1 NZ_CP070494:705473-705715 [Methylomonas sp. EFPC1]
MQTLTASEARTNLYRLIDQANESHEPITITGKRSNAVLLSAQDWSAIQETLFLLSVPGMRESIIEGMATPADECSKELDW

Download         Length: 243 bp

>AT194176 NZ_CP093376:20093-20416 [Cronobacter sakazakii]
ATGACAGCAGACATTGAACGCAGTAACGGAAATGTGTATGACGATCTCGGGCTTATCGATGCCGAAGAGATGGAGCTAAA
AGCGCAGCTCGCTATGGCGATTAGCGACATTCTTAAAGCGCGCGGTTTAACCCAACAGGAGGCGGCCCGTCTTCTGGGAA
TGACCCAGCCCAAACTCTCTTTATTACTTCGCGGCCAGTTTCGCGGGATCAGCGAAACGAAAATGATGGCCTGCCTGATG
CTCCTCGGGCGGGATATCAGCATCGTCGTGGGCGAGGCACAGCATGCGCGCGGAAAAATGCGCCTGATCTATCAGCCAGC
CTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References