Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 4193032..4193725 Replicon chromosome
Accession NZ_CP070482
Organism Escherichia coli strain BTH101

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag JWV29_RS20340 Protein ID WP_000415584.1
Coordinates 4193032..4193328 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag JWV29_RS20345 Protein ID WP_000650107.1
Coordinates 4193330..4193725 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JWV29_RS20305 (4188120) 4188120..4188434 - 315 WP_000958598.1 putative quinol monooxygenase -
JWV29_RS20310 (4188465) 4188465..4189046 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
JWV29_RS20315 (4189365) 4189365..4189697 + 333 WP_000917684.1 DUF2645 family protein -
JWV29_RS20320 (4189743) 4189743..4191092 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
JWV29_RS20325 (4191089) 4191089..4191748 - 660 WP_001221495.1 quorum sensing response regulator transcription factor QseB -
JWV29_RS20330 (4191900) 4191900..4192292 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
JWV29_RS20335 (4192345) 4192345..4192827 + 483 WP_000183505.1 GyrI-like domain-containing protein -
JWV29_RS20340 (4193032) 4193032..4193328 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
JWV29_RS20345 (4193330) 4193330..4193725 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
JWV29_RS20350 (4193858) 4193858..4195465 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
JWV29_RS20355 (4195603) 4195603..4197861 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T194158 WP_000415584.1 NZ_CP070482:4193032-4193328 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T194158 NZ_CP093373:c1109678-1109460 [Salmonella enterica subsp. enterica serovar Infantis]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCTGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT194158 WP_000650107.1 NZ_CP070482:4193330-4193725 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT194158 NZ_CP093373:c1110080-1109706 [Salmonella enterica subsp. enterica serovar Infantis]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References