Detailed information of TA system TA194154

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 3661371..3661593
• Replicon: chromosome
• Accession: NZ_CP070482
• Organism: Escherichia coli strain BTH101

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1E8T8
• Locus tag: JWV29_RS17735
• Protein ID: WP_000141634.1
• Coordinates: 3661486..3661593 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	3661371..3661437 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JWV29_RS17715	3656812..3657714	+	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-
JWV29_RS17720	3657725..3658708	+	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
JWV29_RS17725	3658705..3659709	+	1005	WP_000107012.1	dipeptide ABC transporter ATP-binding subunit DppF	-
JWV29_RS17730	3659739..3661010	-	1272	WP_001295225.1	aromatic amino acid transport family protein	-
-	3661371..3661437	-	67	-	-	Antitoxin
JWV29_RS17735	3661486..3661593	+	108	WP_000141634.1	type I toxin-antitoxin system toxic polypeptide LdrD	Toxin
JWV29_RS17740	3661680..3663359	-	1680	WP_000191622.1	cellulose biosynthesis protein BcsG	-
JWV29_RS17745	3663356..3663547	-	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
JWV29_RS17750	3663544..3665115	-	1572	WP_001204927.1	cellulose biosynthesis c-di-GMP-binding protein BcsE	-
JWV29_RS17755	3665388..3665576	+	189	WP_001063318.1	cellulose biosynthesis protein BcsR	-
JWV29_RS17760	3665612..3666340	+	729	WP_011310329.1	cellulose biosynthesis protein BcsQ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3916.72 Da
• Isoelectric Point: 9.0157

>T194154 WP_000141634.1 NZ_CP070482:3661486-3661593 [Escherichia coli]
MTFAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T194154 NZ_CP093369:4205857-4206321 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin

Nucleotide

• Length: 67 bp

>AT194154 NZ_CP070482:c3661437-3661371 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• PDB: 5LBJ

Antitoxin