Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | yafN-yafO (relBE)/YafO-YafN |
Location | 2465567..2466261 | Replicon | chromosome |
Accession | NZ_CP070482 | ||
Organism | Escherichia coli strain BTH101 |
Toxin (Protein)
Gene name | yafO | Uniprot ID | Q47157 |
Locus tag | JWV29_RS12075 | Protein ID | WP_001263489.1 |
Coordinates | 2465567..2465965 (-) | Length | 133 a.a. |
Antitoxin (Protein)
Gene name | yafN | Uniprot ID | S1QAE3 |
Locus tag | JWV29_RS12080 | Protein ID | WP_000554758.1 |
Coordinates | 2465968..2466261 (-) | Length | 98 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
- (2461155) | 2461155..2461235 | - | 81 | NuclAT_12 | - | - |
- (2461155) | 2461155..2461235 | - | 81 | NuclAT_12 | - | - |
- (2461155) | 2461155..2461235 | - | 81 | NuclAT_12 | - | - |
- (2461155) | 2461155..2461235 | - | 81 | NuclAT_12 | - | - |
JWV29_RS12050 (2461831) | 2461831..2462289 | - | 459 | WP_001291990.1 | xanthine phosphoribosyltransferase | - |
JWV29_RS12055 (2462550) | 2462550..2464007 | + | 1458 | WP_001292994.1 | cytosol nonspecific dipeptidase | - |
JWV29_RS12060 (2464064) | 2464064..2464585 | - | 522 | Protein_2369 | peptide chain release factor H | - |
JWV29_RS12065 (2464581) | 2464581..2464787 | - | 207 | Protein_2370 | RtcB family protein | - |
JWV29_RS12070 (2465105) | 2465105..2465557 | - | 453 | WP_001059892.1 | GNAT family N-acetyltransferase | - |
JWV29_RS12075 (2465567) | 2465567..2465965 | - | 399 | WP_001263489.1 | type II toxin-antitoxin system mRNA interferase toxin YafO | Toxin |
JWV29_RS12080 (2465968) | 2465968..2466261 | - | 294 | WP_000554758.1 | type I toxin-antitoxin system antitoxin YafN | Antitoxin |
JWV29_RS12085 (2466313) | 2466313..2467368 | - | 1056 | WP_001226164.1 | DNA polymerase IV | - |
JWV29_RS12090 (2467439) | 2467439..2468224 | - | 786 | WP_000207552.1 | putative lateral flagellar export/assembly protein LafU | - |
JWV29_RS12095 (2468196) | 2468196..2469908 | + | 1713 | Protein_2376 | flagellar biosynthesis protein FlhA | - |
JWV29_RS12100 (2470132) | 2470132..2470629 | - | 498 | WP_000006255.1 | REP-associated tyrosine transposase RayT | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 133 a.a. Molecular weight: 15487.84 Da Isoelectric Point: 7.4215
>T194147 WP_001263489.1 NZ_CP070482:c2465965-2465567 [Escherichia coli]
MRVFKTKLIRLQLTAEELDALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANENNPFPPQLRQFSRT
NDEAHLVYCQGAFDEQAWLLIAILKPEPHKLARDNNQMHKIGKMAEAFRMRF
MRVFKTKLIRLQLTAEELDALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANENNPFPPQLRQFSRT
NDEAHLVYCQGAFDEQAWLLIAILKPEPHKLARDNNQMHKIGKMAEAFRMRF
Download Length: 399 bp
>T194147 NZ_CP093369:c2911654-2911403 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA
Antitoxin
Download Length: 98 a.a. Molecular weight: 11233.76 Da Isoelectric Point: 5.2170
>AT194147 WP_000554758.1 NZ_CP070482:c2466261-2465968 [Escherichia coli]
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EQYLNDMTDDDFNDFKE
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EQYLNDMTDDDFNDFKE
Download Length: 294 bp
>AT194147 NZ_CP093369:c2911406-2911152 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A090J8B1 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | S1QAE3 |