Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1083666..1084124 Replicon chromosome
Accession NZ_CP070480
Organism Rothia sp. ZJ932

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag JR346_RS05020 Protein ID WP_205483717.1
Coordinates 1083882..1084124 (+) Length 81 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag JR346_RS05015 Protein ID WP_205483887.1
Coordinates 1083666..1083872 (+) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JR346_RS04995 1078968..1080752 + 1785 WP_205483713.1 RNA-directed DNA polymerase -
JR346_RS05000 1081756..1082073 + 318 WP_205482312.1 hypothetical protein -
JR346_RS05005 1082070..1082990 + 921 WP_205483715.1 IS3 family transposase -
JR346_RS05010 1083176..1083583 - 408 WP_205483885.1 transposase family protein -
JR346_RS05015 1083666..1083872 + 207 WP_205483887.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
JR346_RS05020 1083882..1084124 + 243 WP_205483717.1 Txe/YoeB family addiction module toxin Toxin
JR346_RS05025 1084199..1085497 + 1299 WP_205483719.1 carboxylesterase family protein -
JR346_RS05030 1085669..1086753 + 1085 Protein_970 NADH:flavin oxidoreductase/NADH oxidase -
JR346_RS05035 1087196..1087651 + 456 WP_205483721.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
JR346_RS05040 1087696..1088265 + 570 WP_204875753.1 HIT domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1051161..1100725 49564


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-75)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(6-58)


Sequences

Toxin        


Download         Length: 81 a.a.        Molecular weight: 9665.92 Da        Isoelectric Point: 9.7617

>T194131 WP_205483717.1 NZ_CP070480:1083882-1084124 [Rothia sp. ZJ932]
MELIWSENAWEDYLWWQVQDRKTLKRINALLKDIQRNGNEGIGKPEALRNNLSGYWSRRITDEHRLVYKIVGSSVRYHYS

Download         Length: 243 bp

>T194131 NZ_CP093368:4236879-4237343 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7446.26 Da        Isoelectric Point: 4.0606

>AT194131 WP_205483887.1 NZ_CP070480:1083666-1083872 [Rothia sp. ZJ932]
ISLDVDDFEEVVITRAGREPAVIISLAEYESLKETAYLLRSPANARRLLDSIDELESGSGSAHSLIEN

Download         Length: 207 bp

>AT194131 NZ_CP093368:4236544-4236879 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References