194130

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 753718..754231 Replicon chromosome
Accession NZ_CP070480
Organism Rothia sp. ZJ932

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag JR346_RS03500 Protein ID WP_204877080.1
Coordinates 753977..754231 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag JR346_RS03495 Protein ID WP_204877081.1
Coordinates 753718..753972 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JR346_RS03470 749069..749848 + 780 WP_205483839.1 PIG-L family deacetylase -
JR346_RS03475 749852..750280 + 429 WP_205483237.1 hypothetical protein -
JR346_RS03480 750447..750770 + 324 WP_204877084.1 4Fe-4S binding protein -
JR346_RS03485 750941..752080 + 1140 WP_205483246.1 succinyldiaminopimelate transaminase -
JR346_RS03490 752238..753521 + 1284 WP_204877082.1 citrate synthase -
JR346_RS03495 753718..753972 + 255 WP_204877081.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
JR346_RS03500 753977..754231 + 255 WP_204877080.1 Txe/YoeB family addiction module toxin Toxin
JR346_RS03505 754420..755433 - 1014 WP_204877079.1 UDP-glucose 4-epimerase GalE -
JR346_RS03510 755529..756482 - 954 WP_205483248.1 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase -
JR346_RS03515 756542..757678 + 1137 WP_205483249.1 succinyl-diaminopimelate desuccinylase -
JR346_RS03520 757913..758827 - 915 WP_204877076.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10167.65 Da        Isoelectric Point: 8.0689

>T194130 WP_204877080.1 NZ_CP070480:753977-754231 [Rothia sp. ZJ932]
MKIVWDEAAWEDYLWWQVQDRKVLKRINLLIKNIARNGHEGIGKPEALKHDWSGFWSRRITDEHRLIYALTEDSLLIASC
RYHY

Download         Length: 255 bp

>T194130 NZ_CP093368:c4193997-4193683 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9538.80 Da        Isoelectric Point: 5.7189

>AT194130 WP_204877081.1 NZ_CP070480:753718-753972 [Rothia sp. ZJ932]
MKTMTYSESRARYAEVMTSVVDDCEEIVITRAGHEPVVMLSLREYDSLKETAYLKRSPRNAARVSASIERLRSGMGSEHN
LIDE

Download         Length: 255 bp

>AT194130 NZ_CP093368:c4193686-4193270 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References