Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3870810..3871407 Replicon chromosome
Accession NZ_CP070464
Organism Klebsiella pneumoniae strain B28906

Toxin (Protein)


Gene name higB Uniprot ID A0A9J6S5A1
Locus tag JT748_RS18695 Protein ID WP_004893639.1
Coordinates 3871090..3871407 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID R4YH91
Locus tag JT748_RS18690 Protein ID WP_004142561.1
Coordinates 3870810..3871097 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JT748_RS18660 3866890..3867138 + 249 WP_002893037.1 DUF1158 domain-containing protein -
JT748_RS18665 3867156..3867497 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
JT748_RS18670 3867528..3868643 - 1116 WP_012737592.1 MBL fold metallo-hydrolase -
JT748_RS18675 3868823..3869404 + 582 WP_004176968.1 TetR/AcrR family transcriptional regulator -
JT748_RS18680 3869404..3869772 + 369 WP_004142557.1 MmcQ/YjbR family DNA-binding protein -
JT748_RS18685 3869892..3870545 + 654 WP_004178896.1 oxygen-insensitive NAD(P)H nitroreductase -
JT748_RS18690 3870810..3871097 - 288 WP_004142561.1 helix-turn-helix transcriptional regulator Antitoxin
JT748_RS18695 3871090..3871407 - 318 WP_004893639.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JT748_RS18700 3871592..3872635 - 1044 WP_004893645.1 DUF2157 domain-containing protein -
JT748_RS18705 3873301..3874167 - 867 WP_004151823.1 helix-turn-helix transcriptional regulator -
JT748_RS18710 3874276..3875703 + 1428 WP_004176980.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12100.35 Da        Isoelectric Point: 11.2767

>T194115 WP_004893639.1 NZ_CP070464:c3871407-3871090 [Klebsiella pneumoniae]
MFRLVVHVDVKKELQALPSIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

>T194115 NZ_CP093368:c2148161-2148054 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10771.46 Da        Isoelectric Point: 10.2212

>AT194115 WP_004142561.1 NZ_CP070464:c3871097-3870810 [Klebsiella pneumoniae]
MSKKIIDWDTLKTELLGQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp

>AT194115 NZ_CP093368:2148209-2148275 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3DIQ1

References