Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3989260..3989857 Replicon chromosome
Accession NZ_CP070454
Organism Klebsiella quasipneumoniae strain B25110

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag JT746_RS19460 Protein ID WP_049013659.1
Coordinates 3989540..3989857 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JT746_RS19455 Protein ID WP_049013658.1
Coordinates 3989260..3989547 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JT746_RS19425 3985448..3985696 + 249 WP_002893037.1 DUF1158 domain-containing protein -
JT746_RS19430 3985714..3986055 - 342 WP_004202492.1 RamA family antibiotic efflux transcriptional regulator -
JT746_RS19435 3986086..3987201 - 1116 WP_162543091.1 MBL fold metallo-hydrolase -
JT746_RS19440 3987381..3987965 + 585 WP_023288732.1 TetR/AcrR family transcriptional regulator -
JT746_RS19445 3987962..3988330 + 369 WP_004202487.1 MmcQ/YjbR family DNA-binding protein -
JT746_RS19450 3988450..3989103 + 654 WP_023288731.1 oxygen-insensitive NAD(P)H nitroreductase -
JT746_RS19455 3989260..3989547 - 288 WP_049013658.1 helix-turn-helix transcriptional regulator Antitoxin
JT746_RS19460 3989540..3989857 - 318 WP_049013659.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JT746_RS19465 3990042..3991085 - 1044 WP_109546575.1 DUF2157 domain-containing protein -
JT746_RS19470 3991431..3992297 - 867 WP_117140809.1 helix-turn-helix transcriptional regulator -
JT746_RS19475 3992406..3993833 + 1428 WP_048296961.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12102.38 Da        Isoelectric Point: 11.2767

>T194080 WP_049013659.1 NZ_CP070454:c3989857-3989540 [Klebsiella quasipneumoniae]
MFRMVVHVDVKKELQALPAIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

>T194080 NZ_CP070454:c3989857-3989540 [Klebsiella quasipneumoniae]
ATGTTCAGAATGGTTGTGCACGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGGCCATTGTCCAGGCGAAGATGATCAG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGATAGTAAACCGCTGGGGCAGGGGCTATTCGAAA
TTCGGGCGTTAGGTTCGGTACAGGGGCGGGGGATTTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10810.49 Da        Isoelectric Point: 10.2213

>AT194080 WP_049013658.1 NZ_CP070454:c3989547-3989260 [Klebsiella quasipneumoniae]
MSKKIIDWDTLKTELLSQPEVQAAFDAQERQHRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp

>AT194080 NZ_CP070454:c3989547-3989260 [Klebsiella quasipneumoniae]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACGGAACTGCTCAGCCAGCCTGAGGTTCAGGCTGCGTTCGATGC
GCAAGAACGTCAACATCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTGACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCAACGGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCACCCGCAAGTTTTACTTTATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References