Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3874953..3875550 Replicon chromosome
Accession NZ_CP070445
Organism Klebsiella pneumoniae strain B12097

Toxin (Protein)


Gene name higB Uniprot ID R4YIC5
Locus tag JT744_RS18935 Protein ID WP_004142563.1
Coordinates 3875233..3875550 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID R4YH91
Locus tag JT744_RS18930 Protein ID WP_004142561.1
Coordinates 3874953..3875240 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JT744_RS18900 3871048..3871296 + 249 WP_002893037.1 DUF1158 domain-containing protein -
JT744_RS18905 3871314..3871655 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
JT744_RS18910 3871686..3872801 - 1116 WP_012737592.1 MBL fold metallo-hydrolase -
JT744_RS18915 3872981..3873565 + 585 WP_071579668.1 TetR/AcrR family transcriptional regulator -
JT744_RS18920 3873562..3873930 + 369 WP_040171587.1 MmcQ/YjbR family DNA-binding protein -
JT744_RS18925 3874050..3874688 + 639 WP_064277739.1 oxygen-insensitive NAD(P)H nitroreductase -
JT744_RS18930 3874953..3875240 - 288 WP_004142561.1 helix-turn-helix transcriptional regulator Antitoxin
JT744_RS18935 3875233..3875550 - 318 WP_004142563.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JT744_RS18940 3875735..3876778 - 1044 WP_040153598.1 DUF2157 domain-containing protein -
JT744_RS18945 3877448..3878314 - 867 WP_004151823.1 helix-turn-helix transcriptional regulator -
JT744_RS18950 3878423..3879850 + 1428 WP_009308097.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.39 Da        Isoelectric Point: 11.2767

>T194049 WP_004142563.1 NZ_CP070445:c3875550-3875233 [Klebsiella pneumoniae]
MFRLVVHVDVKKELQALPPIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

>T194049 NZ_CP093332:c3984163-3983774 [Buttiauxella ferragutiae]
ATGTACATGCTGGATACCAACACGGTGAGCTATCTTTTCCGTCAGCATCCTAAAGTGATAGAAAAGCTGGCTCAAACGCG
CCCTGTAGAAGTGTGCATTTCTAGTGTAACGGAAGCTGAGCTGTTATATGGCGTGGCTAAGCGCCAGAGTAAAAATCTGG
CTGCGGCGGTGCAGGGTTTTCTGGAAACAGTATCGGTCTACGCGTGGGACAGCGAAGCGGCAAAAAGCTACGGTCAGTTA
CGAGCGGCGATGGAAAAGAAAGGCAAAGTATTGGGTCATCTTGACCAGTTAATTGCCGCTCACGCCCTGAGCCGAAACGC
GACGGTGGTCACCAGCGATCGTGCTTTTACCATGGTCGGGCGTTTACGCGTTGAGGACTGGACGCGCTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10771.46 Da        Isoelectric Point: 10.2212

>AT194049 WP_004142561.1 NZ_CP070445:c3875240-3874953 [Klebsiella pneumoniae]
MSKKIIDWDTLKTELLGQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp

>AT194049 NZ_CP093332:c3984429-3984166 [Buttiauxella ferragutiae]
ATGGAGCGCGTCGCGAAGCTTTTTAAAAACGGCAGAAACCAGGCGGTGAGGTTACCGGTGGAATTTGAGTTTGATACCGA
CAGGGTATATATCCGCAAAGACAAGGAGGGAAACGTGATTCTTTCAAAAAATCCAGCCAAACCAGAAGGATGGGGTAACG
TTTTTGCTTTAGTGAAGAAAGCAAAAGTGCCTGATAACTTCCTTGATGAGCAGGAGCGTAACCAGAGTATTGCCGACAGA
GATCCCTTTGCAGGGATGGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M5MXH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3DIQ1

References