Detailed information of TA system TA193911

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 78794..79452
• Replicon: plasmid pAB5075-VUB-itrA_3
• Accession: NZ_CP070361
• Organism: Acinetobacter baumannii strain AB5075-VUB-itrA::ISAba13

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: JWB57_RS20155
• Protein ID: WP_000312250.1
• Coordinates: 78794..79153 (+)
• Length: 120 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: JWB57_RS20160
• Protein ID: WP_001096429.1
• Coordinates: 79153..79452 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JWB57_RS20120 (JWB57_19820)	74112..75104	-	993	WP_001381192.1	TniB family NTP-binding protein	-
JWB57_RS20125 (JWB57_19825)	75107..75514	-	408	Protein_84	Mu transposase C-terminal domain-containing protein	-
JWB57_RS20130 (JWB57_19830)	75931..76434	-	504	WP_001053125.1	hypothetical protein	-
JWB57_RS20135 (JWB57_19835)	76501..76944	-	444	WP_242934670.1	hypothetical protein	-
JWB57_RS20140 (JWB57_19840)	76998..77729	-	732	WP_242934671.1	hypothetical protein	-
JWB57_RS20145 (JWB57_19845)	77796..77978	-	183	WP_000373385.1	hypothetical protein	-
JWB57_RS20150 (JWB57_19850)	78027..78593	-	567	WP_000710385.1	hypothetical protein	-
JWB57_RS20155 (JWB57_19855)	78794..79153	+	360	WP_000312250.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JWB57_RS20160 (JWB57_19860)	79153..79452	+	300	WP_001096429.1	XRE family transcriptional regulator	Antitoxin
JWB57_RS20165 (JWB57_19865)	79989..80525	-	537	WP_000731978.1	hypothetical protein	-
JWB57_RS20170 (JWB57_19870)	80575..81129	-	555	WP_000790084.1	hypothetical protein	-
JWB57_RS20175 (JWB57_19875)	81149..81367	-	219	WP_001043201.1	hypothetical protein	-
JWB57_RS20180 (JWB57_19880)	81407..82036	-	630	WP_000701003.1	hypothetical protein	-
JWB57_RS20185 (JWB57_19885)	82053..82232	-	180	WP_000387630.1	hypothetical protein	-
JWB57_RS20190 (JWB57_19890)	82208..82780	-	573	WP_242934672.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	aph(3')-VIa / ant(2'')-Ia / cmlA1 / aadA2 / aph(3'')-Ib / aph(6)-Id / blaGES-11 / aac(6')-Ib / dfrA7 / sul1	-	1..87892	87892

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (14-109)

Antitoxin

• HigA2-like, helix-turn-helix domain (12-88)

Sequences

Toxin

Protein

• Length: 120 a.a.
• Molecular weight: 13751.62 Da
• Isoelectric Point: 4.8212

>T193911 WP_000312250.1 NZ_CP070361:78794-79153 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Nucleotide

• Length: 360 bp

>T193911 NZ_CP093280:c353779-353486 [Pseudomonas sp. T1-3-2]
GTGCCACGACTGATTGTTACTCAACGGGCCGTTCAGGGGTTGGAGCGATGCCGCAAATTTTTACTGGAAAAGGGGATTCA
AACAGCGGGGCGTGCGGCGCTGGCTATTGAACGGCAGTTTTCCCTGGTGCAGATGTCCCCTGTCATGGGGCGCCCATTTT
CGTTGGATCCCGAGCTGCGCGAGCTGATCATTGAGTTTGGCGACTCGGGGTATGTCGCGCTGTATAGGTTCGAGCCGAAA
GCCGATGCGGTTTACATCCTGGCGTTCCGGCATCAGAAGGAAGCAGGTTACTGA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11012.93 Da
• Isoelectric Point: 10.4856

>AT193911 WP_001096429.1 NZ_CP070361:79153-79452 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Nucleotide

• Length: 300 bp

>AT193911 NZ_CP093280:c354039-353767 [Pseudomonas sp. T1-3-2]
GTGGCCACTTCAATCAAGATTGATGATGATTTAAAGGACCGTATTCAGCATCTGGCTGCATTGCGTCAACGCACTGCCCA
TTGGCTGATGCGTGAAGCAATTACGGAATATGTTCAGCGCGAAGAAGCTCGGGAGAGCTTCAAGCAGGAAGCCCAGGAGT
CTTGGGCAGCTTATCAGGAGACCGGTTTGCACCTTGATGGCGAACAGGTCAGCGCATGGCTGAAAACCTGGGCTGCAGAT
GAGAAGGCGGAGGCGCCTGAGTGCCACGACTGA