Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2040718..2041637 Replicon chromosome
Accession NZ_CP070338
Organism Mycobacterium tuberculosis strain 11502

Toxin (Protein)


Gene name HigB2 Uniprot ID L7N4R2
Locus tag JR349_RS09375 Protein ID WP_003900449.1
Coordinates 2041032..2041637 (-) Length 202 a.a.

Antitoxin (Protein)


Gene name HigA2 Uniprot ID L7N5K9
Locus tag JR349_RS09370 Protein ID WP_003410124.1
Coordinates 2040718..2041023 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JR349_RS09335 2036179..2036556 + 378 Protein_1851 hypothetical protein -
JR349_RS09340 2036553..2037593 + 1041 WP_003410103.1 ImmA/IrrE family metallo-endopeptidase -
JR349_RS09345 2037835..2038554 + 720 WP_003410108.1 DUF433 domain-containing protein -
JR349_RS09350 2038544..2038774 + 231 Protein_1854 hypothetical protein -
JR349_RS09360 2040130..2040318 + 189 Protein_1856 hypothetical protein -
JR349_RS09365 2040334..2040633 - 300 WP_003410120.1 hypothetical protein -
JR349_RS09370 2040718..2041023 - 306 WP_003410124.1 XRE family transcriptional regulator Antitoxin
JR349_RS09375 2041032..2041637 - 606 WP_003900449.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JR349_RS09380 2041662..2042021 - 360 WP_003410131.1 hypothetical protein -
JR349_RS09385 2042181..2042858 - 678 WP_003905725.1 hypothetical protein -
JR349_RS09390 2042810..2043046 - 237 WP_003410133.1 hypothetical protein -
JR349_RS09395 2043253..2044149 - 897 WP_003410136.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2034867..2050622 15755


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(86-181)

Antitoxin

HigA2-like, helix-turn-helix domain

(32-92)


Sequences

Toxin        


Download         Length: 202 a.a.        Molecular weight: 22744.96 Da        Isoelectric Point: 7.3073

>T193865 WP_003900449.1 NZ_CP070338:c2041637-2041032 [Mycobacterium tuberculosis]
VNVPWENAHGGALYCLIRGDEFSAWHRLLFQRPGCAESVLACRHFLDGSPVARCSYPEEYHPCVISRIALLCDSVGWTAD
VERISAWLNGLDRETYELVFAAIEVLEEEGPALGCPLVDTVRGSRHKNMKELRPGSQGRSEVRILFAFDPARQAIMLAAG
NKAGRWTQWYDEKIKAADEMFAEHLAQFEDTKPKRRKRKKG

Download         Length: 606 bp

>T193865 NZ_CP093245:c2453264-2452854 [Moellerella wisconsensis]
GTGGTCCTGTGGAAATCTAATTTATCCATATCATGGATGGCTCAGCTTTTTTCTACCTGTGTACATTGTGTCCTGGGGCT
AGTGTTATTACTGGCTCCGTGGCCGACAGGTAACTCTATTATTTGGCTTCCTTTATTAATGGTGACTATTGCGAGTTGGG
CAAAAAGTCAAAAAAACATTAATAAATACAAAGGAATAATTGTTCTTACTAATGGGAATAAAGTCCAATGGAAGAAAAAT
GAATGGAGTATTATCACTCCTCCATGGTGTACTCGCTTTGGTATTTTATTAACGTTAAGTGCATTACAAGGTAAACCTAG
AAAAATAAAATTATGGATTGCAGCTGATGCAATATCAGAAGACGATTGGCGAAATTTAAATCAGTTATTATTACAATATC
CTGATATATAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11291.91 Da        Isoelectric Point: 10.7482

>AT193865 WP_003410124.1 NZ_CP070338:c2041023-2040718 [Mycobacterium tuberculosis]
MAMTLRDMDAVRPVNREAVDRHKARMRDEVRAFRLRELRAAQSLTQVQVAALAHIRQSRVSSIENGDIGSAQVNTLRKYV
SALGGELDITVRLGDETFTLA

Download         Length: 306 bp

>AT193865 NZ_CP093245:c2453511-2453245 [Moellerella wisconsensis]
ATGGATATTGATAATAAAGCGCGGATCCACTGGGCATGTCGTCGAGGAATGCGAGAACTAGATATTTCAATCATGCCTTT
TTTTGAACATGAGTATGATGGATTAAACGATAATGAAAAACACCAGTTTATTCGTTTGCTGGAGTGTGCAGATCCCGATC
TGTTCAATTGGTTGATGAACCATGGTCGTCCTGACGATGATGAGCTTTATCATATGATTAAACTAATTCAACAAAGAAAT
AAAGACCGTGGTCCTGTGGAAATCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BV20

Antitoxin

Source ID Structure
PDB 7EWC
PDB 7EWD
PDB 7EWE
AlphaFold DB A0A7U4BV30

References