Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/Gp49-HTH_37 |
| Location | 1970178..1971046 | Replicon | chromosome |
| Accession | NZ_CP070338 | ||
| Organism | Mycobacterium tuberculosis strain 11502 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | P9WJA4 |
| Locus tag | JR349_RS08960 | Protein ID | WP_010886136.1 |
| Coordinates | 1970178..1970555 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | G0TLM0 |
| Locus tag | JR349_RS08965 | Protein ID | WP_003409886.1 |
| Coordinates | 1970597..1971046 (+) | Length | 150 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JR349_RS08910 | 1965967..1966419 | - | 453 | WP_003899095.1 | lipoprotein | - |
| JR349_RS08915 | 1966483..1966884 | + | 402 | WP_003409869.1 | hypothetical protein | - |
| JR349_RS08920 | 1966877..1967059 | - | 183 | WP_003409870.1 | hypothetical protein | - |
| JR349_RS08925 | 1967173..1967523 | - | 351 | WP_003409871.1 | hypothetical protein | - |
| JR349_RS08930 | 1967534..1968436 | - | 903 | WP_003899097.1 | hypothetical protein | - |
| JR349_RS08935 | 1968457..1968648 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| JR349_RS08940 | 1968649..1968945 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| JR349_RS08945 | 1969185..1969400 | + | 216 | WP_003409878.1 | antitoxin | - |
| JR349_RS08950 | 1969397..1969708 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| JR349_RS08955 | 1969682..1970203 | - | 522 | WP_003904745.1 | hypothetical protein | - |
| JR349_RS08960 | 1970178..1970555 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | Toxin |
| JR349_RS08965 | 1970597..1971046 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | Antitoxin |
| JR349_RS08970 | 1971043..1971588 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| JR349_RS08975 | 1971477..1972091 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| JR349_RS08980 | 1972140..1972436 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| JR349_RS08985 | 1972433..1972684 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| JR349_RS08990 | 1972671..1973165 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| JR349_RS08995 | 1973325..1973732 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| JR349_RS09000 | 1973736..1974008 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| JR349_RS09005 | 1974041..1975261 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14397.77 Da Isoelectric Point: 10.8862
>T193859 WP_010886136.1 NZ_CP070338:1970178-1970555 [Mycobacterium tuberculosis]
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI
Download Length: 378 bp
>T193859 NZ_CP093243:c129846-129457 [Moellerella wisconsensis]
GTGGCGTTCTATAAAATCTCATCTTTTGTCCGAAGCACCAAAAAAATACCTATAACAGACAAACAGTTACTTGATGCTGC
TCATGAAGTTCAACAAGGACAATTTGAAGCTGATTTAGGCGGTGGAGTGATAAAAAAACGCCTTGCAATGAAAGGGCAAG
GCAAAAGTGGAAGTGTTAGGGTTATTATCTTTTTTAAGATAAACAATCATCTTTTTTTTGCAGATGGATGGACCAAAAAC
ACGGTCAATGCCAAAGGTACAAAAGAGATTGAAGATGATGAGTTGGAAACCTATAAAAAATTAGCCGCTGAGTTTCTGAA
CTTTGATGGAGAAATCATTAACAATTTAATTTCTAAAGGAATTCTGGAGGAAATTACTGATGAACAATAA
GTGGCGTTCTATAAAATCTCATCTTTTGTCCGAAGCACCAAAAAAATACCTATAACAGACAAACAGTTACTTGATGCTGC
TCATGAAGTTCAACAAGGACAATTTGAAGCTGATTTAGGCGGTGGAGTGATAAAAAAACGCCTTGCAATGAAAGGGCAAG
GCAAAAGTGGAAGTGTTAGGGTTATTATCTTTTTTAAGATAAACAATCATCTTTTTTTTGCAGATGGATGGACCAAAAAC
ACGGTCAATGCCAAAGGTACAAAAGAGATTGAAGATGATGAGTTGGAAACCTATAAAAAATTAGCCGCTGAGTTTCTGAA
CTTTGATGGAGAAATCATTAACAATTTAATTTCTAAAGGAATTCTGGAGGAAATTACTGATGAACAATAA
Antitoxin
Download Length: 150 a.a. Molecular weight: 16760.16 Da Isoelectric Point: 8.0771
>AT193859 WP_003409886.1 NZ_CP070338:1970597-1971046 [Mycobacterium tuberculosis]
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA
Download Length: 450 bp
>AT193859 NZ_CP093243:c129467-129138 [Moellerella wisconsensis]
ATGAACAATAAACTTAATAACATGCTTGAATTGGCTAAAGAGTTAAATGCAGCTGGTGCATCACCTGAAAGCCTGGTTAA
AGATATTGAAAGCACCATCCGTGCTCGTGAAATTAACGATAAAATAAAAGAAGTTTCAGCGATGAGCGGCTCTGAGATCA
AGATGTTGCGGACTAAATATTGTATGTCTCAATCTGTGCTCGCTCGTGCATTGGGAATGTCGAAAGAGAGCATATCCAAA
TGGGAGCGAGGAGAAAAGAAACCAAGCGGCCCTGCATTGAGGATGCTACGTATTCTTGAAAGCAAAGGCCCAGAAGTTTT
AGTGGTCTAA
ATGAACAATAAACTTAATAACATGCTTGAATTGGCTAAAGAGTTAAATGCAGCTGGTGCATCACCTGAAAGCCTGGTTAA
AGATATTGAAAGCACCATCCGTGCTCGTGAAATTAACGATAAAATAAAAGAAGTTTCAGCGATGAGCGGCTCTGAGATCA
AGATGTTGCGGACTAAATATTGTATGTCTCAATCTGTGCTCGCTCGTGCATTGGGAATGTCGAAAGAGAGCATATCCAAA
TGGGAGCGAGGAGAAAAGAAACCAAGCGGCCCTGCATTGAGGATGCTACGTATTCTTGAAAGCAAAGGCCCAGAAGTTTT
AGTGGTCTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|