Detailed information of TA system TA193830

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/-
• Location: 1080561..1081210
• Replicon: chromosome
• Accession: NZ_CP070327
• Organism: MAG: Ferrovum myxofaciens isolate MI1I

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A8F3DXY1
• Locus tag: JVY19_RS05275
• Protein ID: WP_031599590.1
• Coordinates: 1080561..1080899 (+)
• Length: 113 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A8F3E163
• Locus tag: JVY19_RS05280
• Protein ID: WP_031599591.1
• Coordinates: 1080896..1081210 (+)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JVY19_RS05240 (JVY19_05260)	1075577..1076161	+	585	WP_273145884.1	chorismate lyase	-
JVY19_RS05245 (JVY19_05265)	1076240..1076881	+	642	WP_062187741.1	response regulator transcription factor	-
JVY19_RS05250 (JVY19_05270)	1076889..1079024	-	2136	WP_273145885.1	DUF748 domain-containing protein	-
JVY19_RS05255 (JVY19_05275)	1079028..1079180	-	153	WP_273145886.1	hypothetical protein	-
JVY19_RS05260 (JVY19_05280)	1079177..1079611	-	435	WP_150112405.1	cytochrome C	-
JVY19_RS05265 (JVY19_05285)	1079782..1080108	-	327	WP_031596839.1	type II toxin-antitoxin system PemK/MazF family toxin	-
JVY19_RS05270 (JVY19_05290)	1080105..1080326	-	222	WP_082783138.1	antitoxin MazE family protein	-
JVY19_RS05275 (JVY19_05295)	1080561..1080899	+	339	WP_031599590.1	toxin	Toxin
JVY19_RS05280 (JVY19_05300)	1080896..1081210	+	315	WP_031599591.1	transcriptional regulator	Antitoxin
JVY19_RS05285 (JVY19_05305)	1081716..1081937	-	222	WP_082783138.1	antitoxin MazE family protein	-
JVY19_RS05290 (JVY19_05310)	1082106..1082528	-	423	WP_031599221.1	type II toxin-antitoxin system VapC family toxin	-
JVY19_RS05295 (JVY19_05315)	1082525..1082839	-	315	WP_031599223.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
JVY19_RS05300 (JVY19_05320)	1083166..1085061	-	1896	WP_062187752.1	GGDEF domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (42-101)

Sequences

Toxin

Protein

• Length: 113 a.a.
• Molecular weight: 13116.21 Da
• Isoelectric Point: 10.4094

>T193830 WP_031599590.1 NZ_CP070327:1080561-1080899 [Ferrovum myxofaciens]
MKALFVELPSFARFRADYLSDDSFRALQNTLMKNPEAGDIIEGSGGLRKLRHADVKRGKGKRGGLRVIYFWWNAGRQFWL
FTLYDKNEMDDLTMKGKGLLRDMLKLELEERR

Nucleotide

• Length: 339 bp

>T193830 NZ_CP093227:c102693-102277 [Escherichia coli]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAACCTGAAGCATTGCTTAAGCACCT
GGAGCAGTCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGTGCCACCGGTC
CGAAGGCCTCGCCACGCCACGTGCAACTGGTTGACGCGTTCTGTGAGAGGCTCGATGCCGTCCTGCCGTGGGACCGCGCC
GCGGTGGATGCGACCACGGAGATTAAGGTGGCACTGCGTCTCGCCGGCACGCCGATCGGTCCGAACGACACGGCGATAGC
CGGACACGCCATCGCTGCCTGTGCCATTCTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 12006.75 Da
• Isoelectric Point: 9.8220

>AT193830 WP_031599591.1 NZ_CP070327:1080896-1081210 [Ferrovum myxofaciens]
MKNRNLFAEIAEGFNALAEERAGKRTLRTHEVDMIPTSEVTADELLALREKLNLSRPVFARYLRTNPRTLENWEQGRARP
NAQAALLIRLVERYPDTMERLATV

Nucleotide

• Length: 315 bp

>AT193830 NZ_CP093227:c102920-102690 [Escherichia coli]
ATGAGAACCGTATCCATTTTTAAAAATGGCAACAACCGTGCTATCCGCCTTCCACGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGCCCCGTCCGGCCGACCTGGGGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGACTTTATGACGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGAGTTAACCTGTGA