Detailed information of TA system TA193826

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 2783403..2783710
• Replicon: chromosome
• Accession: NZ_CP070306
• Organism: Staphylococcus sp. SM9054

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: JQN77_RS13745
• Protein ID: WP_072353918.1
• Coordinates: 2783534..2783710 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2783403..2783542 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JQN77_RS13705	2778969..2779148	+	180	WP_000669789.1	hypothetical protein	-
JQN77_RS13710	2779459..2779719	+	261	WP_001791826.1	hypothetical protein	-
JQN77_RS13715	2779772..2780122	-	351	WP_000702262.1	complement inhibitor SCIN-A	-
JQN77_RS13720	2780632..2780967	-	336	Protein_2664	SH3 domain-containing protein	-
JQN77_RS13725	2781619..2782110	-	492	WP_000920041.1	staphylokinase	-
JQN77_RS13730	2782301..2783056	-	756	WP_000861038.1	CHAP domain-containing protein	-
JQN77_RS13735	2783068..2783322	-	255	WP_000611512.1	phage holin	-
JQN77_RS13740	2783374..2783481	+	108	WP_001791821.1	hypothetical protein	-
-	2783403..2783542	+	140	NuclAT_0	-	Antitoxin
-	2783403..2783542	+	140	NuclAT_0	-	Antitoxin
-	2783403..2783542	+	140	NuclAT_0	-	Antitoxin
-	2783403..2783542	+	140	NuclAT_0	-	Antitoxin
JQN77_RS13745	2783534..2783710	-	177	WP_072353918.1	putative holin-like toxin	Toxin
JQN77_RS13750	2783853..2784227	-	375	WP_000340977.1	hypothetical protein	-
JQN77_RS13755	2784283..2784570	-	288	WP_001262620.1	hypothetical protein	-
JQN77_RS13760	2784616..2784768	-	153	WP_001000058.1	hypothetical protein	-
JQN77_RS13765	2784761..2788543	-	3783	WP_001836550.1	phage protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6810.43 Da
• Isoelectric Point: 9.9479

>T193826 WP_072353918.1 NZ_CP070306:c2783710-2783534 [Staphylococcus sp. SM9054]
MDRWWLSEYKEVVPMLALLKSLERRCLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T193826 NZ_CP093226:c4172725-4172375 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GTGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTT
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT193826 NZ_CP070306:2783403-2783542 [Staphylococcus sp. SM9054]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Antitoxin