Detailed information of TA system TA193821

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 1073290..1073474
• Replicon: chromosome
• Accession: NZ_CP070306
• Organism: Staphylococcus sp. SM9054

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: JQN77_RS05185
• Protein ID: WP_000482647.1
• Coordinates: 1073290..1073397 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	1073414..1073474 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JQN77_RS05160	1068662..1069135	+	474	WP_000456489.1	GyrI-like domain-containing protein	-
JQN77_RS05165	1069258..1070469	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
JQN77_RS05170	1070651..1071310	-	660	WP_000831298.1	membrane protein	-
JQN77_RS05175	1071370..1072512	-	1143	WP_001176863.1	glycerate kinase	-
JQN77_RS05180	1072770..1073156	+	387	WP_000779360.1	flippase GtxA	-
JQN77_RS05185	1073290..1073397	+	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	1073414..1073474	-	61	-	-	Antitoxin
JQN77_RS05190	1074101..1075864	+	1764	WP_001064814.1	ABC transporter ATP-binding protein/permease	-
JQN77_RS05195	1075889..1077622	+	1734	WP_000486494.1	ABC transporter ATP-binding protein/permease	-
JQN77_RS05200	1077853..1078020	+	168	WP_001790576.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T193821 WP_000482647.1 NZ_CP070306:1073290-1073397 [Staphylococcus sp. SM9054]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T193821 NZ_CP093226:2657790-2657897 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT193821 NZ_CP070306:c1073474-1073414 [Staphylococcus sp. SM9054]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin