Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1041491..1041990 Replicon chromosome
Accession NZ_CP070306
Organism Staphylococcus sp. SM9054

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag JQN77_RS05045 Protein ID WP_000074044.1
Coordinates 1041748..1041990 (+) Length 81 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YBB2
Locus tag JQN77_RS05040 Protein ID WP_000587618.1
Coordinates 1041491..1041748 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQN77_RS05020 1036564..1037757 + 1194 WP_000675411.1 MFS transporter -
JQN77_RS05025 1037988..1038737 - 750 WP_000072459.1 hypothetical protein -
JQN77_RS05030 1038932..1040509 + 1578 Protein_974 FMN-binding glutamate synthase family protein -
JQN77_RS05035 1040677..1041132 - 456 WP_000732082.1 DUF1307 domain-containing protein -
JQN77_RS05040 1041491..1041748 + 258 WP_000587618.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JQN77_RS05045 1041748..1041990 + 243 WP_000074044.1 Txe/YoeB family addiction module toxin Toxin
JQN77_RS05050 1042347..1043423 + 1077 WP_001836950.1 M42 family metallopeptidase -
JQN77_RS05055 1043671..1044333 + 663 WP_000923523.1 ATP-binding cassette domain-containing protein -
JQN77_RS05060 1044326..1045102 + 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
JQN77_RS05065 1045498..1046685 + 1188 WP_000026189.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-79)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 81 a.a.        Molecular weight: 9649.18 Da        Isoelectric Point: 10.1469

>T193820 WP_000074044.1 NZ_CP070306:1041748-1041990 [Staphylococcus sp. SM9054]
MSNYTVKIKNSAKLDLKKTFIEIVETLKNNPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLILSAWSHYD

Download         Length: 243 bp

>T193820 NZ_CP093226:2657255-2657362 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9762.78 Da        Isoelectric Point: 4.1958

>AT193820 WP_000587618.1 NZ_CP070306:1041491-1041748 [Staphylococcus sp. SM9054]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT193820 NZ_CP093226:c2657208-2657142 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB T1YBB2

References