Detailed information of TA system TA193808

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 1044243..1044742
• Replicon: chromosome
• Accession: NZ_CP070305
• Organism: Staphylococcus sp. SM3655

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: JQN76_RS05065
• Protein ID: WP_000074044.1
• Coordinates: 1044500..1044742 (+)
• Length: 81 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YBB2
• Locus tag: JQN76_RS05060
• Protein ID: WP_000587618.1
• Coordinates: 1044243..1044500 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JQN76_RS05040	1039316..1040509	+	1194	WP_000675411.1	MFS transporter	-
JQN76_RS05045	1040740..1041489	-	750	WP_000072459.1	hypothetical protein	-
JQN76_RS05050	1041684..1043261	+	1578	Protein_978	FMN-binding glutamate synthase family protein	-
JQN76_RS05055	1043429..1043884	-	456	WP_000732082.1	DUF1307 domain-containing protein	-
JQN76_RS05060	1044243..1044500	+	258	WP_000587618.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
JQN76_RS05065	1044500..1044742	+	243	WP_000074044.1	Txe/YoeB family addiction module toxin	Toxin
JQN76_RS05070	1045099..1046175	+	1077	WP_001836950.1	M42 family metallopeptidase	-
JQN76_RS05075	1046423..1047085	+	663	WP_000923523.1	ATP-binding cassette domain-containing protein	-
JQN76_RS05080	1047078..1047854	+	777	WP_000072147.1	iron export ABC transporter permease subunit FetB	-
JQN76_RS05085	1048250..1049437	+	1188	WP_000026189.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (6-79)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 81 a.a.
• Molecular weight: 9649.18 Da
• Isoelectric Point: 10.1469

>T193808 WP_000074044.1 NZ_CP070305:1044500-1044742 [Staphylococcus sp. SM3655]
MSNYTVKIKNSAKLDLKKTFIEIVETLKNNPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLILSAWSHYD

Nucleotide

• Length: 243 bp

>T193808 NZ_CP093226:c611912-611448 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGTTCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9762.78 Da
• Isoelectric Point: 4.1958

>AT193808 WP_000587618.1 NZ_CP070305:1044243-1044500 [Staphylococcus sp. SM3655]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT193808 NZ_CP093226:c612247-611912 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Structures

Antitoxin

• AlphaFold DB: T1YBB2