Detailed information of TA system TA193787

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symE-ohsC/SymE(toxin)
• Location: 4058815..4059227
• Replicon: chromosome
• Accession: NZ_CP070296
• Organism: Escherichia albertii strain Sample 165

Toxin (Protein)

• Gene name: symE
• Uniprot ID: A0A7U8ZC55
• Locus tag: JRC44_RS19840
• Protein ID: WP_025237738.1
• Coordinates: 4058886..4059227 (+)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	ohsC
Locus tag	-
Coordinates	4058815..4058891 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JRC44_RS19830 (4055710)	4055710..4057299	+	1590	WP_137649060.1	type I restriction-modification system methyltransferase	-
JRC44_RS19835 (4057296)	4057296..4058658	+	1363	Protein_3924	restriction endonuclease subunit S	-
- (4058815)	4058815..4058891	-	77	NuclAT_6	-	Antitoxin
- (4058815)	4058815..4058891	-	77	NuclAT_6	-	Antitoxin
- (4058815)	4058815..4058891	-	77	NuclAT_6	-	Antitoxin
- (4058815)	4058815..4058891	-	77	NuclAT_6	-	Antitoxin
- (4058815)	4058815..4058891	-	77	NuclAT_7	-	Antitoxin
- (4058815)	4058815..4058891	-	77	NuclAT_7	-	Antitoxin
- (4058815)	4058815..4058891	-	77	NuclAT_7	-	Antitoxin
- (4058815)	4058815..4058891	-	77	NuclAT_7	-	Antitoxin
JRC44_RS19840 (4058886)	4058886..4059227	+	342	WP_025237738.1	endoribonuclease SymE	Toxin
JRC44_RS26585 (4059274)	4059274..4060440	-	1167	WP_077696034.1	DUF1524 domain-containing protein	-
JRC44_RS26590 (4060479)	4060479..4061370	-	892	Protein_3927	DUF262 domain-containing protein	-
JRC44_RS19850 (4061595)	4061595..4061768	+	174	Protein_3928	GntR family transcriptional regulator	-
JRC44_RS19855 (4061920)	4061920..4062851	-	932	Protein_3929	Rpn family recombination-promoting nuclease/putative transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12310.12 Da
• Isoelectric Point: 7.8219

>T193787 WP_025237738.1 NZ_CP070296:4058886-4059227 [Escherichia albertii]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTAIDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQEFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T193787 NZ_CP093221:1964882-1965289 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Nucleotide

• Length: 77 bp

>AT193787 NZ_CP070296:c4058891-4058815 [Escherichia albertii]
AGTCATGATTACTATTCTCCATAAATAGTGATTGTGATGAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: A0A7U8ZC55

Antitoxin