Detailed information of TA system TA193785

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3982482..3982740
• Replicon: chromosome
• Accession: NZ_CP070296
• Organism: Escherichia albertii strain Sample 165

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: JRC44_RS19470
• Protein ID: WP_000809168.1
• Coordinates: 3982588..3982740 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	3982482..3982539 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JRC44_RS19455	3978289..3979536	-	1248	WP_025237694.1	hypothetical protein	-
JRC44_RS19460	3979690..3981183	-	1494	WP_025237695.1	sulfatase-like hydrolase/transferase	-
JRC44_RS19465	3981204..3981965	-	762	WP_001276206.1	outer membrane protein OmpK	-
-	3982482..3982539	-	58	-	-	Antitoxin
JRC44_RS19470	3982588..3982740	+	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
JRC44_RS19475	3982849..3983979	-	1131	WP_001118445.1	molecular chaperone DnaJ	-
JRC44_RS19480	3984068..3985984	-	1917	WP_000516135.1	molecular chaperone DnaK	-
JRC44_RS19485	3986359..3986763	+	405	WP_000833521.1	DUF2541 family protein	-
JRC44_RS19490	3986790..3987503	+	714	WP_001102345.1	acidic protein MsyB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T193785 WP_000809168.1 NZ_CP070296:3982588-3982740 [Escherichia albertii]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T193785 NZ_CP093221:1771251-1771565 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT193785 NZ_CP070296:c3982539-3982482 [Escherichia albertii]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin