Detailed information of TA system TA193760

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 26236..26490
• Replicon: plasmid pESA139_2
• Accession: NZ_CP070294
• Organism: Escherichia albertii strain Sample 166

Toxin (Protein)

• Gene name: srnB
• Uniprot ID: G9G1E3
• Locus tag: JRC43_RS24310
• Protein ID: WP_001312851.1
• Coordinates: 26341..26490 (+)
• Length: 50 a.a.

Antitoxin (RNA)

Gene name	srnC
Locus tag	-
Coordinates	26236..26297 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JRC43_RS24275 (21975)	21975..22946	+	972	WP_001103691.1	plasmid segregation protein ParM	-
JRC43_RS24280 (22951)	22951..23343	+	393	WP_000340829.1	plasmid partitioning/stability family protein	-
JRC43_RS24285 (23348)	23348..24107	-	760	Protein_29	DUF4113 domain-containing protein	-
JRC43_RS24290 (24103)	24103..24765	+	663	Protein_30	conjugative transfer relaxase/helicase TraI	-
JRC43_RS24295 (24758)	24758..25312	+	555	WP_208634911.1	fertility inhibition protein FinO	-
JRC43_RS24300 (25448)	25448..25660	+	213	WP_096949658.1	hypothetical protein	-
JRC43_RS24305 (25906)	25906..25980	+	75	Protein_33	endonuclease	-
- (26236)	26236..26297	-	62	NuclAT_0	-	Antitoxin
- (26236)	26236..26297	-	62	NuclAT_0	-	Antitoxin
- (26236)	26236..26297	-	62	NuclAT_0	-	Antitoxin
- (26236)	26236..26297	-	62	NuclAT_0	-	Antitoxin
JRC43_RS24310 (26341)	26341..26490	+	150	WP_001312851.1	Hok/Gef family protein	Toxin
JRC43_RS24315 (26774)	26774..27031	+	258	WP_000083845.1	replication regulatory protein RepA	-
JRC43_RS25735 (27048)	27048..27299	-	252	WP_223195197.1	replication protein RepA	-
JRC43_RS25740 (27290)	27290..27337	+	48	WP_229471593.1	hypothetical protein	-
JRC43_RS24325 (27330)	27330..27812	+	483	WP_001273588.1	hypothetical protein	-
JRC43_RS24330 (27805)	27805..28374	+	570	Protein_39	plasmid replication initiator RepA	-
JRC43_RS24335 (28484)	28484..28753	+	270	WP_000079946.1	type II toxin-antitoxin system antitoxin YacA	-
JRC43_RS24340 (28753)	28753..29031	+	279	WP_001384452.1	type II toxin-antitoxin system toxin YacB	-
JRC43_RS24345 (29077)	29077..29502	+	426	Protein_42	3'-5' exonuclease	-
JRC43_RS24350 (29667)	29667..30191	+	525	WP_000823671.1	superoxide dismutase family protein	-
JRC43_RS24355 (30453)	30453..30878	+	426	WP_000422741.1	transposase	-
JRC43_RS24360 (30875)	30875..31225	+	351	WP_000624722.1	IS66 family insertion sequence element accessory protein TnpB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	cofA	1..85397	85397

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (4-45)

Sequences

Toxin

Protein

• Length: 50 a.a.
• Molecular weight: 5542.67 Da
• Isoelectric Point: 8.7678

>T193760 WP_001312851.1 NZ_CP070294:26341-26490 [Escherichia albertii]
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK

Nucleotide

• Length: 150 bp

>T193760 NZ_CP093208:2006490-2006678 [Staphylococcus epidermidis]
ATGAGCTTACATTTCCAAATTTTGCTGTGGCTTTCTATCTTATTTATCATCGCAGGAACGATATTATTGGTAACAATGCT
TAAAACTAAAAAAGAAGAACGAAAAGAATCTTATCTAGGCTTTACTGTAATTTTCTTAATCTTTGGTTTTGCCATCTTAA
TTTATACTTTTATATTCGGAATTTTATAA

Antitoxin

Nucleotide

• Length: 62 bp

>AT193760 NZ_CP070294:c26297-26236 [Escherichia albertii]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Structures

Toxin

• AlphaFold DB: A0A829C8K5

Antitoxin