Detailed information of TA system TA193752

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symE-ohsC/SymE(toxin)
• Location: 4080821..4081233
• Replicon: chromosome
• Accession: NZ_CP070292
• Organism: Escherichia albertii strain Sample 166

Toxin (Protein)

• Gene name: symE
• Uniprot ID: A0A7U8ZC55
• Locus tag: JRC43_RS19945
• Protein ID: WP_025237738.1
• Coordinates: 4080892..4081233 (+)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	ohsC
Locus tag	-
Coordinates	4080821..4080897 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JRC43_RS19935 (4077716)	4077716..4079305	+	1590	WP_025237737.1	type I restriction-modification system methyltransferase	-
JRC43_RS19940 (4079302)	4079302..4080664	+	1363	Protein_3955	restriction endonuclease subunit S	-
- (4080821)	4080821..4080897	-	77	NuclAT_6	-	Antitoxin
- (4080821)	4080821..4080897	-	77	NuclAT_6	-	Antitoxin
- (4080821)	4080821..4080897	-	77	NuclAT_6	-	Antitoxin
- (4080821)	4080821..4080897	-	77	NuclAT_6	-	Antitoxin
- (4080821)	4080821..4080897	-	77	NuclAT_7	-	Antitoxin
- (4080821)	4080821..4080897	-	77	NuclAT_7	-	Antitoxin
- (4080821)	4080821..4080897	-	77	NuclAT_7	-	Antitoxin
- (4080821)	4080821..4080897	-	77	NuclAT_7	-	Antitoxin
JRC43_RS19945 (4080892)	4080892..4081233	+	342	WP_025237738.1	endoribonuclease SymE	Toxin
JRC43_RS25590 (4081280)	4081280..4082446	-	1167	WP_077696034.1	DUF1524 domain-containing protein	-
JRC43_RS25595 (4082485)	4082485..4083376	-	892	Protein_3958	DUF262 domain-containing protein	-
JRC43_RS19955 (4083601)	4083601..4083774	+	174	Protein_3959	GntR family transcriptional regulator	-
JRC43_RS19960 (4083926)	4083926..4084857	-	932	Protein_3960	Rpn family recombination-promoting nuclease/putative transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4080308..4091151	10843

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12310.12 Da
• Isoelectric Point: 7.8219

>T193752 WP_025237738.1 NZ_CP070292:4080892-4081233 [Escherichia albertii]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTAIDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQEFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T193752 NZ_CP093205:912181-912543 [Staphylococcus epidermidis]
ATGATTAGAAGAGGAGATGTTTATTTAGCGGATTTATCACCAGTTCAAGGGTCTGAACAAGGGGGAGTAAGACCTGTAGT
TATCATTCAAAATGATACTGGTAATAAATATAGTCCAACTGTAATTGTAGCTGCGATTACTGGTAGGATTAATAAAGCGA
AAATACCAACCCACGTAGAAATTGAAAAGAAAAAGTATAAATTAGACAAAGATTCAGTTATTCTTCTTGAACAAATTAGA
ACACTAGATAAAAAGCGTTTAAAAGAAAAATTAACATTTTTATCAGAGAGTAAAATGATAGAGGTTGATAATGCCTTAGA
TATTAGTTTGGGATTAAATAACTTTGATCATCATAAATCTTAA

Antitoxin

Nucleotide

• Length: 77 bp

>AT193752 NZ_CP070292:c4080897-4080821 [Escherichia albertii]
AGTCATGATTACTATTCTCCATAAATAGTGATTGTGATGAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: A0A7U8ZC55

Antitoxin