Detailed information of TA system TA193734

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1156391..1156637
• Replicon: chromosome
• Accession: NZ_CP070292
• Organism: Escherichia albertii strain Sample 166

Toxin (Protein)

• Gene name: hokX
• Uniprot ID: S1PD89
• Locus tag: JRC43_RS05590
• Protein ID: WP_000956458.1
• Coordinates: 1156485..1156637 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokX
Locus tag	-
Coordinates	1156391..1156443 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JRC43_RS05575	1151795..1153594	+	1800	WP_025238480.1	NADPH-dependent assimilatory sulfite reductase flavoprotein subunit	-
JRC43_RS05580	1153594..1155306	+	1713	WP_025238481.1	assimilatory sulfite reductase (NADPH) hemoprotein subunit	-
JRC43_RS05585	1155486..1156220	+	735	WP_025238482.1	phosphoadenosine phosphosulfate reductase	-
-	1156391..1156443	-	53	-	-	Antitoxin
JRC43_RS05590	1156485..1156637	+	153	WP_000956458.1	Hok/Gef family protein	Toxin
JRC43_RS05595	1156763..1157800	-	1038	WP_025238483.1	alkaline phosphatase isozyme conversion aminopeptidase	-
JRC43_RS05600	1158053..1158961	+	909	WP_000372392.1	sulfate adenylyltransferase subunit CysD	-
JRC43_RS05605	1158963..1160390	+	1428	WP_025238484.1	sulfate adenylyltransferase subunit CysN	-
JRC43_RS05610	1160390..1160995	+	606	WP_024164730.1	adenylyl-sulfate kinase	-
JRC43_RS05615	1161045..1161368	+	324	WP_001246114.1	DUF3561 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (5-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5558.77 Da
• Isoelectric Point: 7.6757

>T193734 WP_000956458.1 NZ_CP070292:1156485-1156637 [Escherichia albertii]
MLTKYALVAIIVLCCTVLGFTLMVGDSLCELSIRERGMEFKAVLAYESKK

Nucleotide

• Length: 153 bp

>T193734 NZ_CP093193:1018740-1018919 [Staphylococcus epidermidis]
ATGGCGAACAAAAAAGATTCCAAATTAAATTATCATGAAGAAGAAAATGCTATGGTTACCGACTTAGATGATTTAAAAGA
ATTAGGAAAAGAAATGGAACAGATTTCACAGGAAAATGATGAAGAAAAATTAAATCAATCTCATGATAACGAAGTTCGTT
CAGATTTAAAAAAACAGTAA

Antitoxin

Nucleotide

• Length: 53 bp

>AT193734 NZ_CP070292:c1156443-1156391 [Escherichia albertii]
TTAGGTTCGAACGTAGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Structures

Toxin

• AlphaFold DB: A0A4P7TJ83

Antitoxin