Detailed information of TA system TA193722

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3753172..3753430
• Replicon: chromosome
• Accession: NZ_CP070290
• Organism: Escherichia albertii strain Sample 167

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: JRC41_RS17955
• Protein ID: WP_000809168.1
• Coordinates: 3753278..3753430 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	3753172..3753229 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JRC41_RS17940	3748979..3750226	-	1248	WP_059214856.1	hypothetical protein	-
JRC41_RS17945	3750380..3751873	-	1494	WP_059214855.1	sulfatase-like hydrolase/transferase	-
JRC41_RS17950	3751894..3752655	-	762	WP_001276206.1	outer membrane protein OmpK	-
-	3753172..3753229	-	58	-	-	Antitoxin
JRC41_RS17955	3753278..3753430	+	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
JRC41_RS17960	3753538..3754668	-	1131	WP_001118445.1	molecular chaperone DnaJ	-
JRC41_RS17965	3754757..3756673	-	1917	WP_000516135.1	molecular chaperone DnaK	-
JRC41_RS17970	3757048..3757452	+	405	WP_000833521.1	DUF2541 family protein	-
JRC41_RS17975	3757479..3758192	+	714	WP_001102345.1	acidic protein MsyB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T193722 WP_000809168.1 NZ_CP070290:3753278-3753430 [Escherichia albertii]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T193722 NZ_CP093181:c1879753-1879391 [Staphylococcus epidermidis]
ATGATTAGAAGAGGAGATGTTTATTTAGCGGATTTATCACCAGTTCAAGGGTCTGAACAAGGGGGAGTAAGACCTGTAGT
TATCATTCAAAATGATACTGGTAATAAATATAGTCCAACTGTAATTGTAGCTGCGATTACTGGTAGGATTAATAAAGCGA
AAATACCAACCCACGTAGAAATTGAAAAGAAAAAGTATAAATTAGACAAAGATTCAGTTATTCTTCTTGAACAAATTAGA
ACACTAGATAAAAAGCGTTTAAAAGAAAAATTAACATTTTTATCAGAGAGTAAAATGATAGAGGTTGATAATGCCTTAGA
TATTAGTTTGGGATTAAATAACTTTGATCATCATAAATCTTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT193722 NZ_CP070290:c3753229-3753172 [Escherichia albertii]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin