Detailed information of TA system TA193720

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 2312214..2312776
• Replicon: chromosome
• Accession: NZ_CP070290
• Organism: Escherichia albertii strain Sample 167

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A7U8ZNU8
• Locus tag: JRC41_RS11100
• Protein ID: WP_000605679.1
• Coordinates: 2312214..2312492 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: JRC41_RS11105
• Protein ID: WP_000781369.1
• Coordinates: 2312492..2312776 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JRC41_RS11080 (2308194)	2308194..2308625	-	432	WP_059225291.1	peroxiredoxin OsmC	-
JRC41_RS11085 (2308892)	2308892..2309029	+	138	WP_000841563.1	stationary-phase-induced ribosome-associated protein	-
JRC41_RS11090 (2309186)	2309186..2310883	+	1698	WP_000433442.1	malate dehydrogenase	-
JRC41_RS11095 (2311018)	2311018..2312028	+	1011	WP_000642386.1	alcohol dehydrogenase AdhP	-
JRC41_RS11100 (2312214)	2312214..2312492	+	279	WP_000605679.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JRC41_RS11105 (2312492)	2312492..2312776	+	285	WP_000781369.1	HigA family addiction module antitoxin	Antitoxin
JRC41_RS11110 (2313004)	2313004..2313657	-	654	WP_000045636.1	formate dehydrogenase-N subunit gamma	-
JRC41_RS11115 (2313650)	2313650..2314534	-	885	WP_001240583.1	formate dehydrogenase N subunit beta	-
JRC41_RS11120 (2314547)	2314547..2317594	-	3048	WP_077776584.1	formate dehydrogenase-N subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-92)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (3-81)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10533.10 Da
• Isoelectric Point: 7.3995

>T193720 WP_000605679.1 NZ_CP070290:2312214-2312492 [Escherichia albertii]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAASSLVDIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Nucleotide

• Length: 279 bp

>T193720 NZ_CP093181:c1566518-1566339 [Staphylococcus epidermidis]
ATGGCGAACAAAAAAGATTCCAAATTAAATTATCATGAAGAAGAAAATGCTATGGTTACCGACTTAGATGATTTAAAAGA
ATTAGGAAAAGAAATGGAACAGATTTCACAGGAAAATGATGAAGAAAAATTAAATCAATCTCATGATAACGAAGTTCGTT
CAGATTTAAAAAAACAGTAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10371.06 Da
• Isoelectric Point: 8.8567

>AT193720 WP_000781369.1 NZ_CP070290:2312492-2312776 [Escherichia albertii]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVAQ

Nucleotide

• Length: 285 bp

>AT193720 NZ_CP093181:c1567141-1566542 [Staphylococcus epidermidis]
ATGGCAATGAATTTTAAAGTATTTGATAATAGTGAAAAAGTAGCAGAATATACTGCAGATATTCTACGTAAGCAGTTTAA
TAATAATCCAACTACTATTGCAGGATTTCATTTGAGCAAAGAACATGCACCAGTGTTTGATGAACTTAAGAAAAATGTAG
AAAATCATACAGTTGATTTCAGTCAAATAAATATTTTAGATTATGATGATAATCATTCTTATTATGAGGCTTTGGGTGTG
CCAACAGGCCAAATTTATTCCATTTCTTACGAAAATGATGCAATTGACTTTATCTCAGATAAGATTAAGACTAAAGAAAA
TAAAGGCAAACTGACAATGCAAGTCCTTACGATTGATGAAAATGGTAAACTTGACATTAGCGTTCGTCAAGGTTTGATGG
AAGCTAGAGAAATTTTCTTAGTTATTACTGGTGCTAATAAACGCGATATGGTAGAAAAACTTTACCGTGAAAATGGTAAG
ACTAGTTTTGAACCATCGGATTTAAAAGCACACCGTATGGTCAATGTTATCTTAGATAAAGAAGCGGCTGCAGGCTTACC
TGAAGACGTAAAAGAGTACTTCACTGCACGTTTTGCATAA

Structures

Toxin

• AlphaFold DB: A0A7U8ZNU8